Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
about
MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instabilityDiffering patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNAAssociation of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations.Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatinMutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female miceMicrosatellite instability in colorectal cancerOverexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugsDNA mismatch repair: molecular mechanism, cancer, and ageingMuir-Torre-like syndrome in Fhit-deficient miceMolecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesisManipulation of DNA Repair Proficiency in Mouse Models of Colorectal CancerReport on the use of non-clinical studies in the regulatory evaluation of oncology drugsMouse models for the discovery of colorectal cancer driver genesColorectal cancer models for novel drug discoveryModeling the study of DNA damage responses in miceA MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesMismatch repair polymorphisms and colorectal polyps: hMLH1-93G>A variant modifies risk associated with smokingReplicative DNA polymerase δ but not ε proofreads errors in Cis and in TransMechanisms and functions of DNA mismatch repairA panoply of errors: polymerase proofreading domain mutations in cancerDNA replication error-induced extinction of diploid yeastMutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshiftsSomatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution patternThe Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA SynthesisCaveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae.Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ miceExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationElevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cellsElevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epitheliumDifferent mutator phenotypes in Mlh1- versus Pms2-deficient miceIsolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalphaExtracolonic manifestations of lynch syndromeIdentification of key transcription factors in caerulein-induced pancreatitis through expression profiling data.Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain.Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.Mouse models of colorectal cancer.Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications.Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes
P2860
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P2860
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
description
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
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im November 1997 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 1997/11/14)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/11/14)
@nl
наукова стаття, опублікована в листопаді 1997
@uk
مقالة علمية (نشرت في 14-11-1997)
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name
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
@ast
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
@en
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
@nl
type
label
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
@ast
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
@en
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
@nl
prefLabel
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
@ast
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
@en
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
@nl
P2093
P3181
P1433
P1476
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility
@en
P2093
G. F. Crouse
J. R. Lipford
J. W. Pollard
M. F. Kane
P304
P3181
P356
10.1016/S0092-8674(00)80433-X
P407
P577
1997-11-14T00:00:00Z