Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs - Wikidata - awgldk - TriplyDB

Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs

Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs

http://www.wikidata.org/entity/Q24644933

about

Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1 APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability Repression of mutagenesis by Rad51D-mediated homologous recombination.Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer Emerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical example Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4 DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair Redundancy in ribonucleotide excision repair: Competition, compensation, and cooperation Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ Enhanced expression and activity of DNA polymerase beta in human ovarian tumor cells: impact on sensitivity towards antitumor agents DNA damage response genes and the development of cancer metastasis A role for DNA polymerase beta in mutagenic UV lesion bypass Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha.DNA polymerase β contains a functional nuclear localization signal at its N-terminus.DNA repair and gene therapy: implications for translational uses.Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase.DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability Base excision repair in a network of defence and tolerance.Structural basis for the inefficient nucleotide incorporation opposite cisplatin-DNA lesion by human DNA polymerase β.RNA aptamers selected against DNA polymerase beta inhibit the polymerase activities of DNA polymerases beta and kappa.Potential application of curcumin and its analogues in the treatment strategy of patients with primary epithelial ovarian cancer.Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features Two novel determinants of etoposide resistance in small cell lung cancer.DNA polymerase beta and mammalian base excision repair.Real-time surface plasmon resonance study of biomolecular interactions between polymerase and bulky mutagenic DNA lesions.PPARalpha agonist-induced rodent tumors: modes of action and human relevance.DNA polymerase beta is critical for genomic stability of sperm cells.Molecular mechanisms of resistance and toxicity associated with platinating agents.Effects of base excision repair gene polymorphisms on pancreatic cancer survival Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms DNA polymerase β gap-filling translesion DNA synthesis Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase.Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.Imbalanced adaptive responses associated with microsatellite instability in cholangiocarcinoma Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.

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P2860

Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs

http://www.wikidata.org/entity/Q24644933

description

1998 nî lūn-bûn

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1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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1998 թվականի հոտեմբերին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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Overexpression of DNA polymera ...... ensitivity to anticancer drugs

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Overexpression of DNA polymera ...... ensitivity to anticancer drugs

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Overexpression of DNA polymera ...... ensitivity to anticancer drugs

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Overexpression of DNA polymera ...... ensitivity to anticancer drugs

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Overexpression of DNA polymera ...... ensitivity to anticancer drugs

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Overexpression of DNA polymera ...... ensitivity to anticancer drugs

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Overexpression of DNA polymera ...... ensitivity to anticancer drugs

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Overexpression of DNA polymera ...... ensitivity to anticancer drugs

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B Salles

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C Cazaux

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K Bouayadi

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P2860

Mutations of mitotic checkpoint genes in human cancers

Characterization of DNA polymerase beta mRNA: cell-cycle and growth response in cultured human cells

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

Cell cycle control and cancer

DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene.

Is cisplatin a human carcinogen?

Fork-like DNA templates support bypass replication of lesions that block DNA synthesis on single-stranded templates.

Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells

Mutator phenotype may be required for multistage carcinogenesis.

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