Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus
about
Mechanisms of HIV protein degradation into epitopes: implications for vaccine designCTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitopeHigh epitope expression levels increase competition between T cellsThe type 1 diabetes - HLA susceptibility interactome--identification of HLA genotype-specific disease genes for type 1 diabetes.A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirusProteasomes shape the repertoire of T cells participating in antigen-specific immune responses.Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.Ongoing coxsackievirus myocarditis is associated with increased formation and activity of myocardial immunoproteasomesElucidating the catalytic subunit composition of distinct proteasome subtypes: a crosslinking approach employing bifunctional activity-based probes.CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells.Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virusMice completely lacking immunoproteasomes show major changes in antigen presentationThe CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virusPortable flanking sequences modulate CTL epitope processing.Antigen presentation machinery (APM) modulation and soluble HLA molecules in the tumor microenvironment: do they provide tumor cells with escape mechanisms from recognition by cytotoxic T lymphocytes?Human immunodeficiency virus type 1 Gag p24 alters the composition of immunoproteasomes and affects antigen presentation.Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent mannerInhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.The role of the proteasome in the generation of MHC class I ligands and immune responses.Standard and immunoproteasomes show similar peptide degradation specificities.Proteasome subtypes and regulators in the processing of antigenic peptides presented by class I molecules of the major histocompatibility complex.Degradation of heme oxygenase-1 by the immunoproteasome in astrocytes: A potential interferon-γ-dependent mechanism contributing to HIV neuropathogenesis.Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation.Differential presentation of endogenous and exogenous hepatitis B surface antigens influences priming of CD8(+) T cells in an epitope-specific manner.Stable antigen is most effective for eliciting CD8+ T-cell responses after DNA vaccination and infection with recombinant vaccinia virus in vivo.PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.The outcome of cross-priming during virus infection is not directly linked to the ability of the antigen to be cross-presented.No essential role for tripeptidyl peptidase II for the processing of LCMV-derived T cell epitopes.Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis.Cell type-specific proteasomal processing of HIV-1 Gag-p24 results in an altered epitope repertoire.Impaired antigen processing and presentation machinery is associated with immunotolerant state in chronic hepatitis B virus infection.Three immunoproteasome-associated subunits cooperatively generate a cytotoxic T-lymphocyte epitope of Epstein-Barr virus LMP2A by overcoming specific structures resistant to epitope liberation.Antitopes define preferential proteasomal cleavage site usage.The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire.Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome.Distorted relation between mRNA copy number and corresponding major histocompatibility complex ligand density on the cell surface.
P2860
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P2860
Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus
description
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im September 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/09/15)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/09/15)
@nl
наукова стаття, опублікована у вересні 2004
@uk
مقالة علمية (نشرت في 15-9-2004)
@ar
name
Immunoproteasomes down-regulat ...... hocytic choriomeningitis virus
@ast
Immunoproteasomes down-regulat ...... hocytic choriomeningitis virus
@en
Immunoproteasomes down-regulat ...... hocytic choriomeningitis virus
@nl
type
label
Immunoproteasomes down-regulat ...... hocytic choriomeningitis virus
@ast
Immunoproteasomes down-regulat ...... hocytic choriomeningitis virus
@en
Immunoproteasomes down-regulat ...... hocytic choriomeningitis virus
@nl
prefLabel
Immunoproteasomes down-regulat ...... hocytic choriomeningitis virus
@ast
Immunoproteasomes down-regulat ...... hocytic choriomeningitis virus
@en
Immunoproteasomes down-regulat ...... hocytic choriomeningitis virus
@nl
P2093
P921
P1476
Immunoproteasomes down-regulat ...... hocytic choriomeningitis virus
@en
P2093
Maries Van Den Broek
Michael Basler
Michael Przybylski
Nikolay Youhnovski
P304
P356
10.4049/JIMMUNOL.173.6.3925
P407
P577
2004-09-15T00:00:00Z