about
CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2FAT10, a ubiquitin-independent signal for proteasomal degradationNEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradationProstaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cellsThe ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibitionThe UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificityThe proteasome inhibitor bortezomib enhances the susceptibility to viral infectionThe immunoproteasome in antigen processing and other immunological functionsImmunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virusCytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease.Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors.Microencapsulation of inorganic nanocrystals into PLGA microsphere vaccines enables their intracellular localization in dendritic cells by electron and fluorescence microscopy.Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.The inherited blindness protein AIPL1 regulates the ubiquitin-like FAT10 pathwayConjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation.Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells.UBE1L2, a novel E1 enzyme specific for ubiquitin.Activating the ubiquitin family: UBA6 challenges the field.An artificial PAP gene breaks self-tolerance and promotes tumor regression in the TRAMP model for prostate carcinomaPLGA microspheres for improved antigen delivery to dendritic cells as cellular vaccines.A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteinsSubunit specific inhibitors of proteasomes and their potential for immunomodulationAdvances in prostate cancer immunotherapies.A cytomegalovirus inhibitor of gamma interferon signaling controls immunoproteasome induction.Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.Endosomal trafficking of open Major Histocompatibility Class I conformers--implications for presentation of endocytosed antigens.FAT10ylation as a signal for proteasomal degradation.The unique functions of tissue-specific proteasomes.The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense.Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma.The ubiquitin-like modifier FAT10 in cancer development.Using protease inhibitors in antigen presentation assays.NUB1 modulation of GSK3β reduces tau aggregation.Stable antigen is most effective for eliciting CD8+ T-cell responses after DNA vaccination and infection with recombinant vaccinia virus in vivo.Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice.The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA.
P50
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P50
description
onderzoeker
@nl
name
Marcus Groettrup
@ast
Marcus Groettrup
@en
Marcus Groettrup
@es
Marcus Groettrup
@nl
Marcus Groettrup
@sl
type
label
Marcus Groettrup
@ast
Marcus Groettrup
@en
Marcus Groettrup
@es
Marcus Groettrup
@nl
Marcus Groettrup
@sl
prefLabel
Marcus Groettrup
@ast
Marcus Groettrup
@en
Marcus Groettrup
@es
Marcus Groettrup
@nl
Marcus Groettrup
@sl
P106
P21
P31
P569
2000-01-01T00:00:00Z