p63 deficiency activates a program of cellular senescence and leads to accelerated aging
about
Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cellsStxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradationCell density-dependent acetylation of ΔNp63α is associated with p53-dependent cell cycle arrestMicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6TAp63 prevents premature aging by promoting adult stem cell maintenancep63 regulates proliferation and differentiation of developmentally mature keratinocytesThe signaling involving in autophagy machinery in keratinocytes and therapeutic approaches for skin diseasesDNA repair and aging: the impact of the p53 familyGenetics and epigenetics of aging and longevityAberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiencyAn active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fateThe cell cycle as a brake for β-cell regeneration from embryonic stem cellsThe identification of zebrafish mutants showing alterations in senescence-associated biomarkersThe Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineageCross-regulation between Notch and p63 in keratinocyte commitment to differentiationPAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasisDifferential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null miceDysregulated ΔNp63α inhibits expression of Ink4a/arf, blocks senescence, and promotes malignant conversion of keratinocytesSenescent keratinocytes die by autophagic programmed cell death.A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma.TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review.Hepatic p63 regulates steatosis via IKKβ/ER stressMnSOD upregulation induces autophagic programmed cell death in senescent keratinocytes.Tumor suppression by p53: making cells senescent.{Delta}Np73{beta} puts the brakes on DNA repair.Four faces of cellular senescence.TAp63 induces senescence and suppresses tumorigenesis in vivo.p63 and p73, the ancestors of p53.Tracing the protectors path from the germ line to the genome.Long-term α1B-adrenergic receptor activation shortens lifespan, while α1A-adrenergic receptor stimulation prolongs lifespan in association with decreased cancer incidence.Fat tissue, aging, and cellular senescence.p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells.p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.Androgen receptor drives cellular senescence.iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ.ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.Perspectives on cellular senescence and short term dietary restriction in adultsOpposing roles for calcineurin and ATF3 in squamous skin cancer.
P2860
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P2860
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
description
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im September 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/09/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/09/01)
@nl
наукова стаття, опублікована у вересні 2005
@uk
مقالة علمية (نشرت في سبتمبر 2005)
@ar
name
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
@ast
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
@en
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
@nl
type
label
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
@ast
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
@en
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
@nl
prefLabel
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
@ast
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
@en
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
@nl
P2093
P2860
P3181
P356
P1433
P1476
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
@en
P2093
Alea A. Mills
Hannes Vogel
Scott W. Lowe
William M. Keyes
Xuecui Guo
P2860
P304
P3181
P356
10.1101/GAD.342305
P577
2005-09-01T00:00:00Z