Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
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Crystal Structure of the Human NKX2.5 Homeodomain in Complex with DNA TargetSlow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiationTinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across speciesLethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasisNKX2-5, a modifier of skeletal muscle pathology due to RNA toxicity.Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformationPoint mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling.SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes.Impact of aldosterone antagonists on the substrate for atrial fibrillation: aldosterone promotes oxidative stress and atrial structural/electrical remodelingReactive oxygen species suppress cardiac NaV1.5 expression through Foxo1.Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes crucial for maturationKnockdown of embryonic myosin heavy chain reveals an essential role in the morphology and function of the developing heartAn early requirement for nkx2.5 ensures the first and second heart field ventricular identity and cardiac function into adulthoodDifferential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart.TBX5 drives Scn5a expression to regulate cardiac conduction system functionSequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during CardiogenesisWhole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs.Irx3 is required for postnatal maturation of the mouse ventricular conduction systemThe emerging genetic landscape underlying cardiac conduction system function.Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy.Transcription factor ETV1 is essential for rapid conduction in the heart.Developmental origin of postnatal cardiomyogenic progenitor cells.Specification of the cardiac conduction system by transcription factors.Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4.Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle.Mutational spectrum of the NKX2-5 gene in patients with lone atrial fibrillationHeart failure in congenital heart disease: the role of genes and hemodynamics.Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice.Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype.Heart Failure Induced by Perinatal Ablation of Cardiac Myosin Light Chain Kinase.Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation.A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation.Genetic and functional analysis of the NKX2-5 gene promoter in patients with ventricular septal defects.nkx genes establish SHF cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression.Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy
P2860
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P2860
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
description
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2008
@ast
im September 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/09/12)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/09/12)
@nl
наукова стаття, опублікована у вересні 2008
@uk
مقالة علمية (نشرت في 12-9-2008)
@ar
name
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
@ast
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
@en
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
@nl
type
label
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
@ast
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
@en
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
@nl
prefLabel
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
@ast
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
@en
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
@nl
P2093
P2860
P3181
P1433
P1476
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
@en
P2093
Adolfo E. Cuadra
Alexandra J. Walker
Ellen O. Weinberg
Hideko Kasahara
Hiroko Wakimoto
Jonathan T. Lu
Kenji Yasui
Kenneth R. Chien
Laura E. Briggs
Melissa H. Marks
P2860
P304
P3181
P356
10.1161/CIRCRESAHA.108.171835
P577
2008-09-12T00:00:00Z