Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
about
Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2Mutation analysis of FOXF2 in patients with disorders of sex development (DSD) in combination with cleft palateGroup 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability.A genomic approach to the identification and characterization of HOXA13 functional binding elementsStructural basis for sequence specific DNA binding and protein dimerization of HOXA13HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specificationBMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signalingGenetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitaliaTissue-specific requirements of beta-catenin in external genitalia developmentDelineating a conserved genetic cassette promoting outgrowth of body appendagesClassic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytesDi-n-butyl phthalate induced hypospadias relates to autophagy in genital tubercle via the PI3K/Akt/mTOR pathwayFkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis.Bmp7 functions via a polarity mechanism to promote cloacal septation.Sonic hedgehog controls growth of external genitalia by regulating cell cycle kinetics.Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal developmentSimilar causes of various reproductive disorders in early lifeMale Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility.Bone Morphogenetic Protein (BMP) signaling in development and human diseasesEmbryonic origin and remodeling of the urinary and digestive outlets.Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiationSix1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development.DELETION MAPPING OF CRITICAL REGION FOR HYPOSPADIAS, PENOSCROTAL TRANSPOSITION AND IMPERFORATE ANUS ON HUMAN CHROMOSOME 13.LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes.Environmental and genetic contributors to hypospadias: a review of the epidemiologic evidence.Molecular mechanisms of external genitalia developmentFine mapping analysis confirms and strengthens linkage of four chromosomal regions in familial hypospadiasDevelopment of the external genitalia: conserved and divergent mechanisms of appendage patterning.Bmp7 expression and null phenotype in the urogenital system suggest a role in re-organization of the urethral epithelium.The Genetic and Environmental Factors Underlying Hypospadias.Functional and phylogenetic analysis shows that Fgf8 is a marker of genital induction in mammals but is not required for external genital developmentTemporal and spatial dissection of Shh signaling in genital tubercle development.Dosage-dependent hedgehog signals integrated with Wnt/beta-catenin signaling regulate external genitalia formation as an appendicular program.Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.Control of the bone morphogenetic protein 7 gene in developmental and adult life.HOXD13 binds DNA replication origins to promote origin licensing and is inhibited by geminin.Hypospadias and genes related to genital tubercle and early urethral development.Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10, and Wnt5a.Retinoic acid signaling regulates sonic hedgehog and bone morphogenetic protein signalings during genital tubercle development.
P2860
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P2860
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
description
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Juli 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/07/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/07/01)
@nl
наукова стаття, опублікована в липні 2003
@uk
مقالة علمية (نشرت في يوليو 2003)
@ar
name
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
@ast
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
@en
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
@nl
type
label
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
@ast
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
@en
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
@nl
prefLabel
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
@ast
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
@en
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
@nl
P2093
P1433
P1476
Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia
@en
P2093
Emily A. Morgan
H. Scott Stadler
Susan B. Nguyen
Virginia Scott
P304
P407
P577
2003-07-01T00:00:00Z