Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
about
A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat.Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155)Defects in spliceosomal machinery: a new pathway of leukaemogenesisThe significance of spliceosome mutations in chronic lymphocytic leukemiaEngineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?Myeloid malignancies: mutations, models and managementSF3B1 mutations in chronic lymphocytic leukemia.Emerging concepts of epigenetic dysregulation in hematological malignanciesHaploinsufficiency of SF3B4, a component of the pre-mRNA spliceosomal complex, causes Nager syndromeMammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genesIdentification of four genes required for mammalian blastocyst formation.The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia.Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells.Extensive polycistronism and antisense transcription in the mammalian Hox clusters.Splicing factor 3b subunit 4 binds BMPR-IA and inhibits osteochondral cell differentiation.Mechanisms of genome instability induced by RNA-processing defects.A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complexGenetic characterization of SF3B1 mutations in single chronic lymphocytic leukemia cellsThe changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome.Circular RNAs are abundant, conserved, and associated with ALU repeats.Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts.The genomic landscape of chronic lymphocytic leukemia: clinical implications.Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencingLimiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing.Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformationsTargeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial SkeletonAn siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated VirusesA Broad Set of Chromatin Factors Influences SplicingSF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment.Molecular pathophysiology of myelodysplastic syndromes.Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndromeThe zebrafish sf3b1b460 mutant reveals differential requirements for the sf3b1 pre-mRNA processing gene during neural crest development.Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis.Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies.Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders.Splicing factor mutations in myelodysplasia.Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms.Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia.
P2860
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P248
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P2860
Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
description
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im März 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/03/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/03/01)
@nl
наукова стаття, опублікована в березні 2005
@uk
مقالة علمية (نشرت في مارس 2005)
@ar
name
Mammalian polycomb-mediated re ...... ial spliceosomal protein Sf3b1
@ast
Mammalian polycomb-mediated re ...... ial spliceosomal protein Sf3b1
@en
Mammalian polycomb-mediated re ...... ial spliceosomal protein Sf3b1
@nl
type
label
Mammalian polycomb-mediated re ...... ial spliceosomal protein Sf3b1
@ast
Mammalian polycomb-mediated re ...... ial spliceosomal protein Sf3b1
@en
Mammalian polycomb-mediated re ...... ial spliceosomal protein Sf3b1
@nl
prefLabel
Mammalian polycomb-mediated re ...... ial spliceosomal protein Sf3b1
@ast
Mammalian polycomb-mediated re ...... ial spliceosomal protein Sf3b1
@en
Mammalian polycomb-mediated re ...... ial spliceosomal protein Sf3b1
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Mammalian polycomb-mediated re ...... ial spliceosomal protein Sf3b1
@en
P2093
Kyoichi Isono
Marion S. Schmidt-Zachmann
Toshihisa Komori
Yoko Mizutani-Koseki
P2860
P304
P3181
P356
10.1101/GAD.1284605
P577
2005-03-01T00:00:00Z