Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function - Wikidata - awgldk - TriplyDB

Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function

Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function

http://www.wikidata.org/entity/Q28594258

about

The dynamic cilium in human diseases A polycystin-centric view of cyst formation and disease: the polycystins revisited ARPKD and early manifestations of ADPKD: the original polycystic kidney disease and phenocopies Wnt and planar cell polarity signaling in cystic renal disease The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression Ciliopathies Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.Polycystic kidney disease.Extracranial Aneurysms in 2 Patients with Autosomal Recessive Polycystic Kidney Disease Murine Models of Polycystic Kidney Disease.A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5.Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.Autosomal recessive polycystic kidney disease: a hepatorenal fibrocystic disorder with pleiotropic effects MicroRNAs and Polycystic Kidney Disease.Mutations in multiple PKD genes may explain early and severe polycystic kidney disease.Loss of polycystin-1 inhibits Bicc1 expression during mouse development.Incompletely penetrant PKD1 alleles mimic the renal manifestations of ARPKD.Identification of Biomarkers for PKD1 Using Urinary Exosomes.Molecular genetic analysis of PKHD1 by next-generation sequencing in Czech families with autosomal recessive polycystic kidney disease.Congenital anomalies of the kidney and urinary tract: a genetic disorder?Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice.Cystic kidney diseases: many ways to form a cyst.TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease.Cystic diseases of the kidney: ciliary dysfunction and cystogenic mechanisms.miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease.The polycystin complex mediates Wnt/Ca(2+) signalling.Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.Calcium-mediated mechanisms of cystic expansion.Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells.Centrosomes and cilia in human disease.Looking at the (w)hole: magnet resonance imaging in polycystic kidney disease.Transplantation in autosomal recessive polycystic kidney disease: liver and/or kidney?Activation of TRPP2 through mDia1-dependent voltage gating.Recent Progress of the ARegPKD Registry Study on Autosomal Recessive Polycystic Kidney Disease.Expression of polycystins and fibrocystin on primary cilia of lung cells.New Insights into the Molecular Mechanisms Targeting Tubular Channels/Transporters in PKD Development.Renoprotection: focus on TRPV1, TRPV4, TRPC6 and TRPM2.Disease modeling in genetic kidney diseases: mice.Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin.Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD).

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Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function

http://www.wikidata.org/entity/Q28594258

description

2008 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի մարտին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2008

@ast

scientific journal article

@en

vedecký článok (publikovaný 2008/03/01)

@sk

vědecký článek publikovaný v roce 2008

@cs

wetenschappelijk artikel (gepubliceerd op 2008/03/01)

@nl

наукова стаття, опублікована в березні 2008

@uk

مقالة علمية (نشرت في مارس 2008)

@ar

name

Fibrocystin/polyductin modulat ...... stin-2 expression and function

@ast

Fibrocystin/polyductin modulat ...... stin-2 expression and function

@en

Fibrocystin/polyductin modulat ...... stin-2 expression and function

@nl

type

label

Fibrocystin/polyductin modulat ...... stin-2 expression and function

@ast

Fibrocystin/polyductin modulat ...... stin-2 expression and function

@en

Fibrocystin/polyductin modulat ...... stin-2 expression and function

@nl

prefLabel

Fibrocystin/polyductin modulat ...... stin-2 expression and function

@ast

Fibrocystin/polyductin modulat ...... stin-2 expression and function

@en

Fibrocystin/polyductin modulat ...... stin-2 expression and function

@nl

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Journal of the American Society of Nephrology

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Fibrocystin/polyductin modulat ...... stin-2 expression and function

@en

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Alfred L. George

http://www.w3.org/2001/XMLSchema#string

Cunxi Li

http://www.w3.org/2001/XMLSchema#string

Dan Liang

http://www.w3.org/2001/XMLSchema#string

Gilbert Moeckel

http://www.w3.org/2001/XMLSchema#string

Guanqing Wu

http://www.w3.org/2001/XMLSchema#string

Ingyu Kim

http://www.w3.org/2001/XMLSchema#string

Jie Ma

http://www.w3.org/2001/XMLSchema#string

Kwokyin Hui

http://www.w3.org/2001/XMLSchema#string

Ping Zhao

http://www.w3.org/2001/XMLSchema#string

Robert J. Coffey

http://www.w3.org/2001/XMLSchema#string

P2860

Polycystin-2 is an intracellular calcium release channel

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm

The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area

PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells

PKD1 interacts with PKD2 through a probable coiled-coil domain

The TRP channels, a remarkably functional family

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

The ion channel polycystin-2 is required for left-right axis determination in mice

P304

455–468

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scholarly article

P3181

4823840

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P356

10.1681/ASN.2007070770

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3

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19

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2008-03-01T00:00:00Z

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P698

18235088

http://www.w3.org/2001/XMLSchema#string

P921

Polycystin 2, transient receptor potential cation channel

P932

2391052

http://www.w3.org/2001/XMLSchema#string