Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm
about
Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expressionPolycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarityPolycystin-1: a master regulator of intersecting cystic pathwaysCystin localizes to primary cilia via membrane microdomains and a targeting motif.Evidence for a "Pathogenic Triumvirate" in Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney DiseaseWnt9b signaling regulates planar cell polarity and kidney tubule morphogenesisCholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signalingInhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells.Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and functionPolyductin undergoes notch-like processing and regulated release from primary ciliaVirtual-tissue computer simulations define the roles of cell adhesion and proliferation in the onset of kidney cystic diseaseThe cytoplasmic tail of fibrocystin contains a ciliary targeting sequenceExtracranial Aneurysms in 2 Patients with Autosomal Recessive Polycystic Kidney DiseaseKnockdown of bicaudal C in zebrafish (Danio rerio) causes cystic kidneys: a nonmammalian model of polycystic kidney disease.Tissue-specific regulation of the mouse Pkhd1 (ARPKD) gene promoterAutosomal recessive polycystic kidney disease: a hepatorenal fibrocystic disorder with pleiotropic effectsPKHD1 post-transcriptionally modulated by miR-365-1 inhibits cell-cell adhesion.Transcriptional complexity in autosomal recessive polycystic kidney disease.Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1.Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.The cytoplasmic tail of FPC antagonizes the full-length protein in the regulation of mTOR pathwayEpitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin.Immunohistochemical detection of polyductin and co-localization with liver progenitor cell markers during normal and abnormal development of the intrahepatic biliary system and in adult hepatobiliary carcinomas.Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.Diagnosis, pathogenesis, and treatment prospects in cystic kidney disease.Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1.Molecular and cellular pathogenesis of autosomal recessive polycystic kidney disease.Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategiesPolycystic kidney disease and the renal cilium.Ciliary dysfunction in polycystic kidney disease: an emerging model with polarizing potentialGlis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease.Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells.Visualizing renal primary cilia.Caroli's Disease: Current Knowledge of Its Biliary Pathogenesis Obtained from an Orthologous Rat Model.Ciliary subcompartments and cysto-proteins.Expression of polycystins and fibrocystin on primary cilia of lung cells.Development and characterization of a cholangiocyte cell line from the PCK rat, an animal model of Autosomal Recessive Polycystic Kidney Disease.NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour.
P2860
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P2860
Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@ast
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@en
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@en-gb
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@nl
type
label
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@ast
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@en
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@en-gb
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@nl
prefLabel
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@ast
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@en
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@en-gb
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@nl
P2093
P50
P3181
P1433
P1476
Polyductin, the PKHD1 gene pro ...... primary cilium, and cytoplasm
@en
P2093
Ana M G Silva
Lisa M Guay-Woodford
Luís F C Menezes
Mary L Watkins
Stefan Somlo
Yasuyuki Nagasawa
Yiqiang Cai
P304
P3181
P356
10.1111/J.1523-1755.2004.00844.X
P407
P577
2004-10-01T00:00:00Z
P5875
P6179
1001062574