Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum
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Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphologyEarly life exposure to a high fat diet promotes long-term changes in dietary preferences and central reward signalingActivation of the cAMP/protein kinase A signalling pathway by coronin 1 is regulated by cyclin-dependent kinase 5 activitySchizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition.The internal state of medium spiny neurons varies in response to different input signalsCyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosisDopamine depletion alters phosphorylation of striatal proteins in a model of ParkinsonismAttention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like Pathology.Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.Quantitative trait locus analysis identifies rat genomic regions related to amphetamine-induced locomotion and Galpha(i3) levels in nucleus accumbens.Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signalingSynaptic roles of cyclin-dependent kinase 5 & its implications in epilepsyDirect effects of HIV-1 Tat on excitability and survival of primary dorsal root ganglion neurons: possible contribution to HIV-1-associated pain.At the Fulcrum in Health and Disease: Cdk5 and the Balancing Acts of Neuronal Structure and Physiology.Protein kinases and addiction.Zebrafish Rohon-Beard neuron development: cdk5 in the midst.Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity.Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formationInhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine.Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry.The "ups and downs" of signaling cascades in addiction.Pharmacogenomics: a path to predictive medicine for schizophrenia.Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory.Association of protein phosphatase 1 gamma 1 with spinophilin suppresses phosphatase activity in a Parkinson disease model.Addiction: a drug-induced disorder of memory reconsolidation.S-Glutathionylation and Redox Protein Signaling in Drug Addiction.Cdk5 Modulates Long-Term Synaptic Plasticity and Motor Learning in Dorsolateral StriatumCyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity.Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia.Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors.Silencing of CDK5 as potential therapy for Alzheimer's disease.Cdk5 regulates multiple cellular events in neural development, function and disease.The Cdk5 inhibitor Roscovitine increases LTP induction in corticostriatal synapses.Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders.The role of Ca2+ signaling in Parkinson's disease.CDK5 downregulation enhances synaptic plasticity.The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5.p53, Apaf-1, caspase-3, and -9 are dispensable for Cdk5 activation during cell death.CDK5 serves as a major control point in neurotransmitter release.
P2860
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P2860
Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum
description
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2004
@ast
im Februar 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/02/17)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/02/17)
@nl
наукова стаття, опублікована в лютому 2004
@uk
name
Cyclin-dependent kinase 5 regu ...... c transmission in the striatum
@ast
Cyclin-dependent kinase 5 regu ...... c transmission in the striatum
@en
Cyclin-dependent kinase 5 regu ...... c transmission in the striatum
@nl
type
label
Cyclin-dependent kinase 5 regu ...... c transmission in the striatum
@ast
Cyclin-dependent kinase 5 regu ...... c transmission in the striatum
@en
Cyclin-dependent kinase 5 regu ...... c transmission in the striatum
@nl
prefLabel
Cyclin-dependent kinase 5 regu ...... c transmission in the striatum
@ast
Cyclin-dependent kinase 5 regu ...... c transmission in the striatum
@en
Cyclin-dependent kinase 5 regu ...... c transmission in the striatum
@nl
P2860
P50
P921
P3181
P356
P1476
Cyclin-dependent kinase 5 regu ...... c transmission in the striatum
@en
P2860
P304
P3181
P356
10.1073/PNAS.0308652100
P407
P577
2004-02-17T00:00:00Z