A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation
about
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayStructural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activationNon-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptorMapping of a region within the N terminus of Jak1 involved in cytokine receptor interactionCharacterization of the signaling capacities of the novel gp130-like cytokine receptorProtein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cellsReal time analysis of STAT3 nucleocytoplasmic shuttling.Dynamics of receptor and protein transducer homodimerisation.Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor.Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation.Bacteria displaying interleukin-4 mutants stimulate mammalian cells and reflect the biological activities of variant soluble cytokines.Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA.Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machineryBiomolecular interaction analysis of IFN gamma-induced signaling events in whole-cell lysates: prevalence of latent STAT1 in high-molecular weight complexes.Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway.A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction.Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling.Protein kinase C delta associates with the interleukin-6 receptor subunit glycoprotein (gp) 130 via Stat3 and enhances Stat3-gp130 interaction.Dimerization of the interferon type I receptor IFNaR2-2 is sufficient for induction of interferon effector genes but not for full antiviral activity.The cell surface expression level of the human interleukin-5 receptor alpha subunit determines the agonistic/antagonistic balance of the human interleukin-5 E13Q mutein.Phosphorylated STAT5 is releasedp-STAT5 dissociates from the receptor complexp-STAT5A/B dissociates from the Growth Hormone receptorPreassociation of nonactivated STAT3 molecules demonstrated in living cells using bioluminescence resonance energy transfer: a new model of STAT activation?A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130
P2860
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P2860
A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation
description
1997 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im Februar 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/02/21)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/02/21)
@nl
наукова стаття, опублікована в лютому 1997
@uk
name
A single STAT recruitment modu ...... sufficient for STAT activation
@ast
A single STAT recruitment modu ...... sufficient for STAT activation
@en
A single STAT recruitment modu ...... sufficient for STAT activation
@nl
type
label
A single STAT recruitment modu ...... sufficient for STAT activation
@ast
A single STAT recruitment modu ...... sufficient for STAT activation
@en
A single STAT recruitment modu ...... sufficient for STAT activation
@nl
prefLabel
A single STAT recruitment modu ...... sufficient for STAT activation
@ast
A single STAT recruitment modu ...... sufficient for STAT activation
@en
A single STAT recruitment modu ...... sufficient for STAT activation
@nl
P2093
P2860
P356
P1476
A single STAT recruitment modu ...... sufficient for STAT activation
@en
P2093
C. Gerhartz
H. Hermanns
H. Schmitz-Van de Leur
I. Behrmann
J. Tavernier
P. C. Heinrich
P2860
P304
P356
10.1074/JBC.272.8.5269
P407
P577
1997-02-21T00:00:00Z