Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport
about
Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replicationAntiviral response in pandemic influenza virusesExpression of non-structural-1A binding protein in lung epithelial cells is modulated by miRNA-548an on exposure to influenza A virusNS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cellsInfluenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery.Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 proteinA human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulumGeneration of high-yielding influenza A viruses in African green monkey kidney (Vero) cells by reverse geneticsRespiratory syncytial virus infection alters surfactant protein A expression in human pulmonary epithelial cells by reducing translation efficiency3' end mRNA processing: molecular mechanisms and implications for health and diseaseProcessing and transcriptome expansion at the mRNA 3' end in health and disease: finding the right endShutoff of Host Gene Expression in Influenza A Virus and Herpesviruses: Similar Mechanisms and Common ThemesInfluenza B virus ribonucleoprotein is a potent activator of the antiviral kinase PKRMutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cellsThe 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo.Influenza virus activation of the interferon systemInfluenza virus NS1 protein counteracts PKR-mediated inhibition of replication.A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in miceSpecific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in miceMultiple anti-interferon actions of the influenza A virus NS1 proteinTwenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity.Influenza A virus replication induces cell cycle arrest in G0/G1 phaseThe influenza virus NS1 protein as a therapeutic target.Surveillance in Eastern India (2007-2009) revealed reassortment event involving NS and PB1-F2 gene segments among co-circulating influenza A subtypes.Novel influenza virus NS1 antagonists block replication and restore innate immune function.Genetic analysis of influenza virus NS1 gene: a temperature-sensitive mutant shows defective formation of virus particles.Interaction of influenza virus NS1 protein with growth arrest-specific protein 8Influenza C virus NS1 protein upregulates the splicing of viral mRNAs.Innate immune evasion strategies of influenza virusesInfluenza virus ns1 protein induces apoptosis in cultured cells.The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteinsTranslational control of viral gene expression in eukaryotesCytopathogenesis and inhibition of host gene expression by RNA viruses.Adenoviral E1B-55kDa protein inhibits yeast mRNA export and perturbs nuclear structure.A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expression.Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.Novel nuclear herniations induced by nuclear localization of a viral proteinCoupling of termination, 3' processing, and mRNA exportFunctional replacement of the carboxy-terminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains.RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids
P2860
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P2860
Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport
description
1994 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1994
@ast
im Februar 1994 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1994/02/01)
@sk
vědecký článek publikovaný v roce 1994
@cs
wetenschappelijk artikel (gepubliceerd op 1994/02/01)
@nl
наукова стаття, опублікована в лютому 1994
@uk
مقالة علمية (نشرت في فبراير 1994)
@ar
name
Influenza virus NS1 protein in ...... NA nucleocytoplasmic transport
@ast
Influenza virus NS1 protein in ...... NA nucleocytoplasmic transport
@en
Influenza virus NS1 protein in ...... NA nucleocytoplasmic transport
@nl
type
label
Influenza virus NS1 protein in ...... NA nucleocytoplasmic transport
@ast
Influenza virus NS1 protein in ...... NA nucleocytoplasmic transport
@en
Influenza virus NS1 protein in ...... NA nucleocytoplasmic transport
@nl
prefLabel
Influenza virus NS1 protein in ...... NA nucleocytoplasmic transport
@ast
Influenza virus NS1 protein in ...... NA nucleocytoplasmic transport
@en
Influenza virus NS1 protein in ...... NA nucleocytoplasmic transport
@nl
P2093
P2860
P3181
P1433
P1476
Influenza virus NS1 protein in ...... NA nucleocytoplasmic transport
@en
P2093
P2860
P304
P3181
P356
10.1002/J.1460-2075.1994.TB06310.X
P407
P577
1994-02-01T00:00:00Z