Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion
about
Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell linesRestoration of high-level transport activity by human reduced folate carrier/ThTr1 thiamine transporter chimaeras: role of the transmembrane domain 6/7 linker region in reduced folate carrier functionBiology of the major facilitative folate transporters SLC19A1 and SLC46A1Functional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: evidence for a charge-pair associationMembrane topology of mouse stearoyl-CoA desaturase 1Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier.Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method.Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells.Mechanisms of membrane transport of folates into cells and across epithelia.The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket.Infection-dependent nuclear localization of US17, a member of the US12 family of human cytomegalovirus-encoded seven-transmembrane proteins.Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.Topology of transmembrane channel-like gene 1 proteinLocalization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods.Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter.Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues.N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT).Subcellular localization and distribution of the reduced folate carrier in normal rat tissuesResistance to antifolates.Measures of adiposity and body fat distribution in relation to serum folate levels in postmenopausal women in a feeding study.Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells.Characterization of a cysteine-less human reduced folate carrier: localization of a substrate-binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods.Disruption of thiamine uptake and growth of cells by feline leukemia virus subgroup A.Antiepileptic drugs reduce the efficacy of methotrexate chemotherapy through accelerated degradation of the reduced folate carrier by the ubiquitin-proteasome pathway.Genetic and epigenetic alterations of the reduced folate carrier in untreated diffuse large B-cell lymphoma.Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans.Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: localization of a substrate binding domain to transmembrane domains 7-12.Disruption of transport activity in a D93H mutant thiamine transporter 1, from a Rogers Syndrome family.Polarized expression of members of the solute carrier SLC19A gene family of water-soluble multivitamin transporters: implications for physiological function.Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms.Functional role of arginine 373 in substrate translocation by the reduced folate carrier.Mutations in the reduced-folate carrier affect protein localization and stability.Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function.Analysis of the membrane topology for transmembrane domains 7-12 of the human reduced folate carrier by scanning cysteine accessibility methods.Intracellular trafficking/membrane targeting of human reduced folate carrier expressed in Xenopus oocytes.Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function.Extracellular 5-methyltetrahydrofolate import across the plasma membraneClustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
P2860
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P2860
Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion
description
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1999
@ast
im Juni 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/06/04)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/06/04)
@nl
наукова стаття, опублікована в червні 1999
@uk
name
Topological and functional ana ...... emagglutinin epitope insertion
@ast
Topological and functional ana ...... emagglutinin epitope insertion
@en
Topological and functional ana ...... emagglutinin epitope insertion
@nl
type
label
Topological and functional ana ...... emagglutinin epitope insertion
@ast
Topological and functional ana ...... emagglutinin epitope insertion
@en
Topological and functional ana ...... emagglutinin epitope insertion
@nl
prefLabel
Topological and functional ana ...... emagglutinin epitope insertion
@ast
Topological and functional ana ...... emagglutinin epitope insertion
@en
Topological and functional ana ...... emagglutinin epitope insertion
@nl
P2860
P356
P1476
Topological and functional ana ...... emagglutinin epitope insertion
@en
P2093
P. L. Ferguson
W. F. Flintoff
P2860
P304
16269–16278
P356
10.1074/JBC.274.23.16269
P407
P577
1999-06-04T00:00:00Z