Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines
about
Plasma membrane transporters in modern liver pharmacologyFolate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis.Influence of reduced folate carrier and dihydrofolate reductase genes on methotrexate-induced cytotoxicity.SLC19A1 pharmacogenomics summary.The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket.Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemiaThe reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasisStructure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter.Future potential of thymidylate synthase inhibitors in cancer therapy.Resistance to antifolates.Contribution of tumoral and host solute carriers to clinical drug response.Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells.Reduced folate carrier gene silencing in multiple antifolate-resistant tumor cell lines is due to a simultaneous loss of function of multiple transcription factors but not promoter methylation.Characterization of a cysteine-less human reduced folate carrier: localization of a substrate-binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods.Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells.Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates.Disruption of transport activity in a D93H mutant thiamine transporter 1, from a Rogers Syndrome family.Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells.Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest.
P2860
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P2860
Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines
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2002 nî lūn-bûn
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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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Resistance to multiple novel a ...... in human leukaemia cell lines
@ast
Resistance to multiple novel a ...... in human leukaemia cell lines
@en
Resistance to multiple novel a ...... in human leukaemia cell lines
@en-gb
Resistance to multiple novel a ...... in human leukaemia cell lines
@nl
type
label
Resistance to multiple novel a ...... in human leukaemia cell lines
@ast
Resistance to multiple novel a ...... in human leukaemia cell lines
@en
Resistance to multiple novel a ...... in human leukaemia cell lines
@en-gb
Resistance to multiple novel a ...... in human leukaemia cell lines
@nl
prefLabel
Resistance to multiple novel a ...... in human leukaemia cell lines
@ast
Resistance to multiple novel a ...... in human leukaemia cell lines
@en
Resistance to multiple novel a ...... in human leukaemia cell lines
@en-gb
Resistance to multiple novel a ...... in human leukaemia cell lines
@nl
P2093
P2860
P921
P356
P1433
P1476
Resistance to multiple novel a ...... in human leukaemia cell lines
@en
P2093
David G Priest
Gerrit Jansen
Ilan Ifergan
Lilah Rothem
Yotam Kaufman
P2860
P304
P356
10.1042/BJ20020801
P407
P577
2002-11-01T00:00:00Z