Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling
about
Siglecs and immune regulationCD22 and Siglec-G in B cell function and toleranceRethinking mechanisms of autoimmune pathogenesisHigh resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec familyCD22: an inhibitory enigmaNegative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9The elastin receptor complex transduces signals through the catalytic activity of its Neu-1 subunitB cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esteraseDecoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivoMolecular underpinning of B-cell anergy.ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signalingCharacterizing the glycome of the mammalian immune system.CD22 regulates adaptive and innate immune responses of B cells.B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.Isotype control of B cell signaling.A Peptide Mimetic of 5-Acetylneuraminic Acid-Galactose Binds with High Avidity to Siglecs and NKG2D.Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling.Regulation of B-cell entry into the cell cycleDendritic cell-dependent inhibition of B cell proliferation requires CD22Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact.The promise of glycomics, glycan arrays and carbohydrate-based vaccines.Liver membrane proteome glycosylation changes in mice bearing an extra-hepatic tumor.Role and therapeutic potential of Glycodelin A in systemic lupus erythematosus.Cis-trans interactions of cell surface receptors: biological roles and structural basis.CD22 and autoimmune disease.Intravenous immunoglobulin-mediated immunosuppression and the development of an IVIG substitute.B lymphocytes: development, tolerance, and their role in autoimmunity-focus on systemic lupus erythematosus.Sialoside specificity of the siglec family assessed using novel multivalent probes: identification of potent inhibitors of myelin-associated glycoprotein.Carbohydrate nanocarriers in biomedical applications: functionalization and construction.A glycoproteomic approach to identify novel glycomarkers for cancer stem cells.S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors.CD22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of B cells.Modulation of natural killer cell functions by interactions between 2B4 and CD48 in cis and in trans.Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking.The ligand-binding domain of CD22 is needed for inhibition of the B cell receptor signal, as demonstrated by a novel human CD22-specific inhibitor compound.Regulation of B cell functions by the sialic acid-binding receptors siglec-G and CD22.CD22 ligation inhibits downstream B cell receptor signaling and Ca(2+) flux upon activation.CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells.CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity.CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms.
P2860
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P2860
Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling
description
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im Mai 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/05/06)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/05/06)
@nl
наукова стаття, опублікована в травні 2002
@uk
مقالة علمية (نشرت في 6-5-2002)
@ar
name
Sialic acid binding domains of ...... n of B cell receptor signaling
@ast
Sialic acid binding domains of ...... n of B cell receptor signaling
@en
Sialic acid binding domains of ...... n of B cell receptor signaling
@nl
type
label
Sialic acid binding domains of ...... n of B cell receptor signaling
@ast
Sialic acid binding domains of ...... n of B cell receptor signaling
@en
Sialic acid binding domains of ...... n of B cell receptor signaling
@nl
prefLabel
Sialic acid binding domains of ...... n of B cell receptor signaling
@ast
Sialic acid binding domains of ...... n of B cell receptor signaling
@en
Sialic acid binding domains of ...... n of B cell receptor signaling
@nl
P2093
P2860
P3181
P356
P1476
Sialic acid binding domains of ...... n of B cell receptor signaling
@en
P2093
Benjamin G Neel
Henry H Wortis
Paul A McLean
P2860
P304
P3181
P356
10.1084/JEM.20011796
P407
P50
P577
2002-05-01T00:00:00Z