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Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunitySiglecs in the immune systemSiglecs as sensors of self in innate and adaptive immune responsesRethinking mechanisms of autoimmune pathogenesisPathogenic Inflammation and Its Therapeutic Targeting in Systemic Lupus ErythematosusCD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium fluxSHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substratesThe inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activityCD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1CD22: an inhibitory enigmaDefinition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activationIndependent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and NckSialic acid binding domains of CD22 are required for negative regulation of B cell receptor signalingThe tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.From a library of MAG antagonists to nanomolar CD22 ligands.The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells.Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell toleranceRequirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient miceNew functions for the sialic acid-binding adhesion molecule CD22, a member of the growing family of Siglecs.Recent progress in the understanding of B-cell functions in autoimmunity.Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization.CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction.ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signalingSialylated multivalent antigens engage CD22 in trans and inhibit B cell activation.B cell inhibitory receptors and autoimmunity.CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.Basal B-cell receptor signaling in B lymphocytes: mechanisms of regulation and role in positive selection, differentiation, and peripheral survival.A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.Specificity and biologic activities of novel anti-membrane IgM antibodiesDeficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies.Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and Fc gamma RII-mediated B cell suppression.The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytesNegative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase.A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells.Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5Nanoscale organization and dynamics of the siglec CD22 cooperate with the cytoskeleton in restraining BCR signalling.Sialic acids and autoimmune disease.Tonic B-cell and viral ITAM signaling: context is everything.
P2860
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P2860
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Inhibition of the B cell by CD22: a requirement for Lyn
@ast
Inhibition of the B cell by CD22: a requirement for Lyn
@en
Inhibition of the B cell by CD22: a requirement for Lyn
@nl
type
label
Inhibition of the B cell by CD22: a requirement for Lyn
@ast
Inhibition of the B cell by CD22: a requirement for Lyn
@en
Inhibition of the B cell by CD22: a requirement for Lyn
@nl
prefLabel
Inhibition of the B cell by CD22: a requirement for Lyn
@ast
Inhibition of the B cell by CD22: a requirement for Lyn
@en
Inhibition of the B cell by CD22: a requirement for Lyn
@nl
P2860
P50
P356
P1476
Inhibition of the B cell by CD22: a requirement for Lyn
@en
P2093
P2860
P304
P356
10.1084/JEM.187.5.807
P407
P577
1998-03-01T00:00:00Z