Targeting purine and pyrimidine metabolism in human apicomplexan parasites
about
Transition-state inhibitors of purine salvage and other prospective enzyme targets in malariaPlasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal modelStructural and Metabolic Specificity of Methylthiocoformycin for Malarial Adenosine DeaminasesA High-Affinity Adenosine Kinase from Anopheles gambiaeDiscovery of Potent and Selective Inhibitors of Toxoplasma gondii Thymidylate Synthase for Opportunistic InfectionsSmall molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5A screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenaseBCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium bergheiHost reticulocytes provide metabolic reservoirs that can be exploited by malaria parasitesThe Open Form Inducer Approach for Structure-Based Drug Design.A novel clade of unique eukaryotic ribonucleotide reductase R2 subunits is exclusive to apicomplexan parasitesIdentification of inhibitors for putative malaria drug targets among novel antimalarial compounds.Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.Purine and pyrimidine pathways as targets in Plasmodium falciparum.De novo assembly and transcriptome analysis of Plasmodium gallinaceum identifies the Rh5 interacting protein (ripr), and reveals a lack of EBL and RH gene family diversification.UPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan.Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum.Drug-resistant malaria - an insight.Adenylating enzymes in Mycobacterium tuberculosis as drug targets.Pyrimidine Pathway-Dependent and -Independent Functions of the Toxoplasma gondii Mitochondrial Dihydroorotate Dehydrogenase.Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondiiReview of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Inhibition of nucleotide biosynthesis potentiates the antifungal activity of amphotericin B.Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum.Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.Genomics of apicomplexan parasites.Reexamining Chronic Toxoplasma gondii Infection: Surprising Activity for a "Dormant" Parasite.Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.Single tryptophan of disordered loop from Plasmodium falciparum purine nucleoside phosphorylase: involvement in catalysis and microenvironment.Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum.Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.Metabolism of nucleotidesComparative proteomic analysis of virulent and avirulent strains of Toxoplasma gondii reveals strain-specific patterns.A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii.Crystal structures of FMN-bound and FMN-free forms of dihydroorotate dehydrogenase from Trypanosoma brucei.Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development.Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in VitroMetabolic interactions between Toxoplasma gondii and its host
P2860
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P2860
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
description
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
scientific journal article
@en
vedecký článok (publikovaný 2007/01/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/01/01)
@nl
наукова стаття, опублікована в січні 2007
@uk
مقالة علمية (نشرت عام 2007)
@ar
name
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
@ast
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
@en
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
@nl
type
label
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
@ast
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
@en
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
@nl
prefLabel
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
@ast
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
@en
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
@nl
P2860
P1433
P1476
Targeting purine and pyrimidine metabolism in human apicomplexan parasites
@en
P2093
John E. Hyde
P2860
P356
10.2174/138945007779315524
P577
2007-01-01T00:00:00Z