Association of the factor VIII light chain with von Willebrand factor
about
Phenotypes of allo- and autoimmune antibody responses to FVIII characterized by surface plasmon resonanceA mouse model of severe von Willebrand disease: defects in hemostasis and thrombosisDifferential proteolytic activation of factor VIII-von Willebrand factor complex by thrombinThe role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis.Phosphatidylinositol containing lipidic particles reduces immunogenicity and catabolism of factor VIII in hemophilia a miceThe "normal" factor VIII concentration in plasma.Factor VIII and platelets synergistically accelerate cleavage of von Willebrand factor by ADAMTS13 under fluid shear stress.Blood coagulation factors V and VIII: Molecular Mechanisms of Procofactor Activation.Efficacy and safety of long-term prophylaxis in severe hemophilia A dogs following liver gene therapy using AAV vectors.Factor VIII-East Hartford (arginine 1689 to cysteine) has procoagulant activity when separated from von Willebrand factor.Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC Study.Evaluation of von Willebrand factor phenotypes and genotypes in Hemophilia A patients with and without identified F8 mutationsVisualization of an N-terminal fragment of von Willebrand factor in complex with factor VIIIThe influence of von Willebrand factor on factor VIII activity measurementsAssociation of Single Nucleotide Polymorphisms in the ST3GAL4 Gene with VWF Antigen and Factor VIII Activity.P3-P3' residues flanking scissile bonds in factor VIII modulate rates of substrate cleavage and procofactor activation by thrombinA major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function.Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation.Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.The diversity of the immune response to the A2 domain of human factor VIIIAcidic residues C-terminal to the A2 domain facilitate thrombin-catalyzed activation of factor VIII.Mass spectrometry-assisted study reveals that lysine residues 1967 and 1968 have opposite contribution to stability of activated factor VIII.The pro-polypeptide of von Willebrand factor is required for the formation of a functional factor VIII-binding site on mature von Willebrand factor.Binding of Factor VIII to Lipid Nanodiscs Increases its Clotting Function in a Mouse Model of Hemophilia A.The interaction between human blood-coagulation factor VIII and von Willebrand factor. Characterization of a high-affinity binding site on factor VIII.Cleavage at Arg-1689 influences heavy chain cleavages during thrombin-catalyzed activation of factor VIII.FVIII-VWF dos-à-dos.Distinct roles of Ser-764 and Lys-773 at the N terminus of von Willebrand factor in complex assembly with coagulation factor VIIIThrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P1 siteEvidence that a secondary binding and protecting site for factor VIII on von Willebrand factor is highly unlikely.Factor VIII-von Willebrand factor complex inhibits osteoclastogenesis and controls cell survival.Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys36.Identification of Aggregates in Therapeutic Formulations of Recombinant Full-Length Factor VIII Products by Sedimentation Velocity Analytical Ultracentrifugation.factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimerfactor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimerIn vitro and in vivo evaluation of the effect of elevated factor VIII on the thrombogenic process.
P2860
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P2860
Association of the factor VIII light chain with von Willebrand factor
description
1988 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1988
@ast
im Juli 1988 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1988/07/25)
@sk
vědecký článek publikovaný v roce 1988
@cs
wetenschappelijk artikel (gepubliceerd op 1988/07/25)
@nl
наукова стаття, опублікована в липні 1988
@uk
name
Association of the factor VIII light chain with von Willebrand factor
@ast
Association of the factor VIII light chain with von Willebrand factor
@en
Association of the factor VIII light chain with von Willebrand factor
@nl
type
label
Association of the factor VIII light chain with von Willebrand factor
@ast
Association of the factor VIII light chain with von Willebrand factor
@en
Association of the factor VIII light chain with von Willebrand factor
@nl
prefLabel
Association of the factor VIII light chain with von Willebrand factor
@ast
Association of the factor VIII light chain with von Willebrand factor
@en
Association of the factor VIII light chain with von Willebrand factor
@nl
P2093
P3181
P1476
Association of the factor VIII light chain with von Willebrand factor
@en
P2093
C. G. Parker
D. C. Hill-Eubanks
P304
10451–10455
P3181
P407
P577
1988-07-25T00:00:00Z