The diversity of the immune response to the A2 domain of human factor VIII
about
Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cellsExpanding the ortholog approach for hemophilia treatment complicated by factor VIII inhibitorsHigh-throughput epitope binning assays on label-free array-based biosensors can yield exquisite epitope discrimination that facilitates the selection of monoclonal antibodies with functional activity.The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfacesStructure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody.Characterization of a genetically engineered mouse model of hemophilia A with complete deletion of the F8 gene.A subset of high-titer anti-factor VIII A2 domain antibodies is responsive to treatment with factor VIII.High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors.Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstructionEngineering less immunogenic and antigenic FVIII proteins.Innovating immune tolerance induction for haemophilia.Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A.Computer-predicted peptides that mimic discontinuous epitopes on the A2 domain of factor VIII.
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P2860
The diversity of the immune response to the A2 domain of human factor VIII
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The diversity of the immune response to the A2 domain of human factor VIII
@ast
The diversity of the immune response to the A2 domain of human factor VIII
@en
type
label
The diversity of the immune response to the A2 domain of human factor VIII
@ast
The diversity of the immune response to the A2 domain of human factor VIII
@en
prefLabel
The diversity of the immune response to the A2 domain of human factor VIII
@ast
The diversity of the immune response to the A2 domain of human factor VIII
@en
P2093
P2860
P1433
P1476
The diversity of the immune response to the A2 domain of human factor VIII
@en
P2093
Ernest T Parker
John F Healey
Pete Lollar
Rebecca C Markovitz
P2860
P304
P356
10.1182/BLOOD-2012-09-456582
P407
P577
2013-01-24T00:00:00Z