Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment
about
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolismMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressRegulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2bLong chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cellsCharacterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteinsThe transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2bIFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress responseIdentification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating proteinCREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasisJuxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasisIdentification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoterDifferential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cellsA proteolytic pathway that controls the cholesterol content of membranes, cells, and bloodCholesterol feedback: from Schoenheimer's bottle to Scap's MELADLCPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase geneUnsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepA family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factorsDual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processingExploring hepatic hormone actions using a compilation of gene expression profiles.Structure of a site-2 protease family intramembrane metalloproteaseCleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavageThe conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation.The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s DiseaseColocalization of sterol isomerase and sigma(1) receptor at endoplasmic reticulum and nuclear envelope levelInverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane HelixSustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1Differential transcriptional regulation of the human squalene synthase gene by sterol regulatory element-binding proteins (SREBP) 1a and 2 and involvement of 5' DNA sequence elements in the regulationMultiple sequence elements are involved in the transcriptional regulation of the human squalene synthase geneAsparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 proteaseA role for smooth endoplasmic reticulum membrane cholesterol ester in determining the intracellular location and regulation of sterol-regulatory-element-binding protein-2Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysEarly dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathwayElevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 genePIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signalingMaintaining cholesterol homeostasis: sterol regulatory element-binding proteinsCleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studiesDifferential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteinsPROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.
P2860
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P2860
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment
description
1996 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1996
@ast
im Juni 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/06/28)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/06/28)
@nl
наукова стаття, опублікована в червні 1996
@uk
مقالة علمية (نشرت في 28-6-1996)
@ar
name
Sterol-regulated release of SR ...... within a transmembrane segment
@ast
Sterol-regulated release of SR ...... within a transmembrane segment
@en
Sterol-regulated release of SR ...... within a transmembrane segment
@nl
type
label
Sterol-regulated release of SR ...... within a transmembrane segment
@ast
Sterol-regulated release of SR ...... within a transmembrane segment
@en
Sterol-regulated release of SR ...... within a transmembrane segment
@nl
prefLabel
Sterol-regulated release of SR ...... within a transmembrane segment
@ast
Sterol-regulated release of SR ...... within a transmembrane segment
@en
Sterol-regulated release of SR ...... within a transmembrane segment
@nl
P2093
P3181
P1433
P1476
Sterol-regulated release of SR ...... within a transmembrane segment
@en
P2093
E. A. Duncan
J. L. Goldstein
M. S. Brown
R. B. Rawson
P304
P3181
P356
10.1016/S0092-8674(00)81304-5
P407
P577
1996-06-28T00:00:00Z