Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b - Wikidata - awgldk - TriplyDB

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

http://www.wikidata.org/entity/Q24298773

about

BRICHOS - a superfamily of multidomain proteins with diverse functions The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b)Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2 BRI2 (ITM2b) inhibits Abeta deposition in vivo Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail Toward the structure of presenilin/γ-secretase and presenilin homologs Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements The chaperone domain BRICHOS prevents CNS toxicity of amyloid-β peptide in Drosophila melanogaster Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).A functional role for ADAM10 in human immunodeficiency virus type-1 replication Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease.Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases Rab GTPase mediated procollagen trafficking in ascorbic acid stimulated osteoblasts.Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells.Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases.Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells Lessons from a Rare Familial Dementia: Amyloid and Beyond.Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.Toward structural elucidation of the gamma-secretase complex.Intramembrane proteolysis Trafficking of receptor tyrosine kinases to the nucleus Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo Regulated intramembrane proteolysis: signaling pathways and biological functions.Intramembrane proteolysis in regulated protein trafficking.BRICHOS domain associated with lung fibrosis, dementia and cancer--a chaperone that prevents amyloid fibril formation?BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).The familial dementia gene revisited: a missense mutation revealed by whole-exome sequencing identifies ITM2B as a candidate gene underlying a novel autosomal dominant retinal dystrophy in a large family.

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P2860

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

http://www.wikidata.org/entity/Q24298773

description

2008 nî lūn-bûn

@nan

2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հունվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

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Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

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Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

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Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

@nl

type

label

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

@ast

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

@en

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

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Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

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prefLabel

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

@ast

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

@en

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

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Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

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P1433

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P1433

Journal of Biological Chemistry

P1476

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

@en

P2093

Karina Reiss

http://www.w3.org/2001/XMLSchema#string

Lucas Martin

http://www.w3.org/2001/XMLSchema#string

P2860

A stop-codon mutation in the BRI gene associated with familial British dementia

Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Brefeldin A: insights into the control of membrane traffic and organelle structure

P304

1644-52

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P31

scholarly article

P356

10.1074/JBC.M706661200

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P407

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

283

http://www.w3.org/2001/XMLSchema#string

P50

Christian Haass

Elisabeth Kremmer

P577

2008-01-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

17965014

http://www.w3.org/2001/XMLSchema#string

P921

Histocompatibility minor 13

ADAM metallopeptidase domain 10

Signal peptide peptidase like 2C

Signal peptide peptidase like 3

Signal peptide peptidase like 2B

Signal peptide peptidase like 2A

Integral membrane protein 2B