Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys
about
RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturationRab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranesPrenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cellsPrenylation of Rab8 GTPase by type I and type II geranylgeranyl transferasesRab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5AStructure of mammalian protein geranylgeranyltransferase type-IStructures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylationThe putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort proteinModulation of statin-activated shedding of Alzheimer APP ectodomain by ROCKRapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.Structure of Protein Geranylgeranyltransferase-I from the Human Pathogen Candida albicans Complexed with a Lipid SubstrateGDI1 encodes a GDP dissociation inhibitor that plays an essential role in the yeast secretory pathway.Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamilyEquine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, bcl-10Phosphate-binding loop and Rab GTPase function: mutations at Ser29 and Ala30 of Rab5 lead to loss-of-function as well as gain-of-function phenotypeRab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesisRab9 functions in transport between late endosomes and the trans Golgi networkMutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells.Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration.Huntingtin differentially regulates the axonal transport of a sub-set of Rab-containing vesicles in vivo.Conformationally variable Rab protein surface regions mapped by limited proteolysis and homology modelling.Phosphatase of regenerating liver-3 localizes to cyto-membrane and is required for B16F1 melanoma cell metastasis in vitro and in vivoPurification of the CaaX-modified, dynamin-related large GTPase hGBP1 by coexpression with farnesyltransferaseThe alpha-subunit of protein prenyltransferases is a member of the tetratricopeptide repeat family.Site-directed mutations altering the CAAX box of Ste18, the yeast pheromone-response pathway G gamma subunit.Scientific side trips: six excursions from the beaten path.Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycleIdentification of Ras farnesyltransferase inhibitors by microbial screening.Molecular basis for Rab prenylationSingle prenyl-binding site on protein prenyl transferases.Fungal lipopeptide mating pheromones: a model system for the study of protein prenylationPhosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.The functional effect of pathogenic mutations in Rab escort protein 1.Amino- and carboxy-terminal domains of the yeast Rab escort protein are both required for binding of Ypt small G proteins.Biochemical and docking analysis of substrate interactions with polyisoprenylated methylated protein methyl esterase.Specific interactions of Mss4 with members of the Rab GTPase subfamily.Molecular control of Rab activity by GEFs, GAPs and GDI.Triazole-based inhibitors of geranylgeranyltransferase II.Regulation of β2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor
P2860
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P2860
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys
description
1992 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1992
@ast
im Juli 1992 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1992/07/15)
@sk
vědecký článek publikovaný v roce 1992
@cs
wetenschappelijk artikel (gepubliceerd op 1992/07/15)
@nl
наукова стаття, опублікована в липні 1992
@uk
name
Rab geranylgeranyl transferase ...... nating in Cys-X-Cys or Cys-Cys
@ast
Rab geranylgeranyl transferase ...... nating in Cys-X-Cys or Cys-Cys
@en
Rab geranylgeranyl transferase ...... nating in Cys-X-Cys or Cys-Cys
@nl
type
label
Rab geranylgeranyl transferase ...... nating in Cys-X-Cys or Cys-Cys
@ast
Rab geranylgeranyl transferase ...... nating in Cys-X-Cys or Cys-Cys
@en
Rab geranylgeranyl transferase ...... nating in Cys-X-Cys or Cys-Cys
@nl
prefLabel
Rab geranylgeranyl transferase ...... nating in Cys-X-Cys or Cys-Cys
@ast
Rab geranylgeranyl transferase ...... nating in Cys-X-Cys or Cys-Cys
@en
Rab geranylgeranyl transferase ...... nating in Cys-X-Cys or Cys-Cys
@nl
P2093
P1476
Rab geranylgeranyl transferase ...... nating in Cys-X-Cys or Cys-Cys
@en
P2093
J. L. Goldstein
M. C. Seabra
M. S. Brown
P304
14497–14503
P407
P577
1992-07-15T00:00:00Z