Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons
about
Using CellMiner 1.6 for Systems Pharmacology and Genomic Analysis of the NCI-60Using drug response data to identify molecular effectors, and molecular "omic" data to identify candidate drugs in cancerNCI-60 whole exome sequencing and pharmacological CellMiner analysesHigh resolution copy number variation data in the NCI-60 cancer cell lines from whole genome microarrays accessible through CellMinerThe NCI-60 Methylome and Its Integration into CellMiner.Gene expression profiling of 49 human tumor xenografts from in vitro culture through multiple in vivo passages--strategies for data mining in support of therapeutic studies.Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif.Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells.Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.Identification of cancer cell-line origins using fluorescence image-based phenomic screening.Concordance of gene expression and functional correlation patterns across the NCI-60 cell lines and the Cancer Genome Atlas glioblastoma samples.Entry tropism of BK and Merkel cell polyomaviruses in cell cultureIdentification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interactionExpression of microRNAs in the NCI-60 cancer cell-linesDirect quantification of mRNA and miRNA from cell lysates using reverse transcription real time PCR: a multidimensional analysis of the performance of reagents and workflows.Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC.F10 Inhibits Growth of PC3 Xenografts and Enhances the Effects of Radiation Therapy.Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicityCellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set.Modulators of sensitivity and resistance to inhibition of PI3K identified in a pharmacogenomic screen of the NCI-60 human tumor cell line collection.Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination.Current dichotomy between traditional molecular biological and omic research in cancer biology and pharmacology.Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activityAn individualized prognostic signature for gastric cancer patients treated with 5-Fluorouracil-based chemotherapy and distinct multi-omics characteristics of prognostic groups.Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA.Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors.MicroRNAs: relevant tools for a colorectal surgeon?microRNA regulation of cell viability and drug sensitivity in lung cancer.All-Atom MD Predicts Magnesium-Induced Hairpin in Chemically Perturbed RNA Analog of F10 Therapeutic.F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence.Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model.CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute.Visualizing ensembles in structural biology.MicroRNA-224 negatively regulates p21 expression during late neoplastic progression in inflammatory bowel diseaseThe cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2.Integrated analysis of miRNA and mRNA profiles enables target acquisition in human cancers.Uncovering Large-Scale Conformational Change in Molecular Dynamics without Prior Knowledge.Drug resistance related to aberrant glycosylation in colorectal cancer.All-Atom Molecular Dynamics Reveals Mechanism of Zinc Complexation with Therapeutic F10.
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P2860
Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons
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2010 nî lūn-bûn
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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
@zh-hant
2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
Genome-wide mRNA and microRNA ...... e, and topoisomerase 1 poisons
@ast
Genome-wide mRNA and microRNA ...... e, and topoisomerase 1 poisons
@en
Genome-wide mRNA and microRNA ...... e, and topoisomerase 1 poisons
@nl
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label
Genome-wide mRNA and microRNA ...... e, and topoisomerase 1 poisons
@ast
Genome-wide mRNA and microRNA ...... e, and topoisomerase 1 poisons
@en
Genome-wide mRNA and microRNA ...... e, and topoisomerase 1 poisons
@nl
prefLabel
Genome-wide mRNA and microRNA ...... e, and topoisomerase 1 poisons
@ast
Genome-wide mRNA and microRNA ...... e, and topoisomerase 1 poisons
@en
Genome-wide mRNA and microRNA ...... e, and topoisomerase 1 poisons
@nl
P2860
P1476
Genome-wide mRNA and microRNA ...... e, and topoisomerase 1 poisons
@en
P2093
William H Gmeiner
P2860
P304
P356
10.1158/1535-7163.MCT-10-0674
P407
P577
2010-12-01T00:00:00Z