Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
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Molecular functions of thyroid hormones and their clinical significance in liver-related diseasesHypothyroidism enhances tumor invasiveness and metastasis development.A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, serves as a sensor for transcriptional regulationA case-control study of levothyroxine and the risk of colorectal cancerThyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosisMutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas.An improved high throughput protein-protein interaction assay for nuclear hormone receptors.Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAILResearch resource: identification of novel coregulators specific for thyroid hormone receptor-β2.The role of thyroid hormone signaling in the prevention of digestive system cancers.Novel oncogenic actions of TRbeta mutants in tumorigenesis.Thyroid hormone receptor mutations found in renal clear cell carcinomas alter corepressor release and reveal helix 12 as key determinant of corepressor specificity.Isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire.The ability of thyroid hormone receptors to sense t4 as an agonist depends on receptor isoform and on cellular cofactors.Thyroid hormone actions in liver cancer.Genetic features of thyroid hormone receptors.Thyroid Hormone, Cancer, and Apoptosis.microRNAs 424 and 503 are mediators of the anti-proliferative and anti-invasive action of the thyroid hormone receptor beta.The sonic hedgehog-induced type 3 deiodinase facilitates tumorigenesis of basal cell carcinoma by reducing Gli2 inactivation.Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells.A cautionary note as to the use of pBi-L and related luciferase/transgenic vectors in the study of thyroid endocrinology.Thyroid hormone receptor-beta (TR beta 1) impairs cell proliferation by the transcriptional inhibition of cyclins D1, E and A2.Direct effects of thyroid hormones on hepatic lipid metabolism.
P2860
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P2860
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
@ast
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
@en
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
@nl
type
label
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
@ast
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
@en
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
@nl
prefLabel
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
@ast
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
@en
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
@nl
P2860
P356
P1433
P1476
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
@en
P2093
M L Privalsky
P2860
P2888
P304
P356
10.1038/SJ.ONC.1209389
P407
P50
P577
2006-01-23T00:00:00Z
P5875
P6179
1014687161