Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease
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Pharmacoperone Identification for Therapeutic Rescue of Misfolded Mutant ProteinsPharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsPharmacological chaperoning: a primer on mechanism and pharmacologyHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesHypothalamic neurohormones and immune responses.A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptorTransitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.Salt bridge integrates GPCR activation with protein traffickingNormosmic congenital hypogonadotropic hypogonadism due to TAC3/TACR3 mutations: characterization of neuroendocrine phenotypes and novel mutationsThe year in G protein-coupled receptor research.Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.Using automated imaging to interrogate gonadotrophin-releasing hormone receptor trafficking and function.Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadismSalt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation.Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptorsRescue of misrouted GnRHR mutants reveals its constitutive activityEvidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function.The Novel Actions of the Metabolite GnRH-(1-5) are Mediated by a G Protein-Coupled Receptor.TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients.Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.Common α2A and α2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking.Leap of Faith: Does Serum Luteinizing Hormone Always Accurately Reflect Central Reproductive Neuroendocrine Activity?Reproductive physiology of a humanized GnRH receptor mouse model: application in evaluation of human-specific analogs.Pharmacological Chaperones: Beyond Conformational Disorders.GnRH Action
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P2860
Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease
description
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
scientific article (publication date: 27 February 2009)
@en
vedecký článok (publikovaný 2009/02/27)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd op 2009/02/27)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в лютому 2009
@uk
مقالة علمية (نشرت في 27-2-2009)
@ar
name
Trafficking and quality contro ...... receptor in health and disease
@ast
Trafficking and quality contro ...... receptor in health and disease
@en
Trafficking and quality contro ...... receptor in health and disease
@nl
type
label
Trafficking and quality contro ...... receptor in health and disease
@ast
Trafficking and quality contro ...... receptor in health and disease
@en
Trafficking and quality contro ...... receptor in health and disease
@nl
prefLabel
Trafficking and quality contro ...... receptor in health and disease
@ast
Trafficking and quality contro ...... receptor in health and disease
@en
Trafficking and quality contro ...... receptor in health and disease
@nl
P2860
P1476
Trafficking and quality contro ...... receptor in health and disease
@en
P2093
Jo Ann Janovick
P Michael Conn
P2860
P304
P356
10.1016/J.MCE.2008.10.051
P407
P577
2009-02-27T00:00:00Z