Salt bridge integrates GPCR activation with protein trafficking
about
Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch.Congenital hypogonadotropic hypogonadism due to GnRH receptor mutations in three brothers reveal sites affecting conformation and couplingA phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptorTransitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.Lineage-specific restraint of pituitary gonadotroph cell adenoma growth.Chaperoning G protein-coupled receptors: from cell biology to therapeuticsRestoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation.Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptorsRescue of misrouted GnRHR mutants reveals its constitutive activityReceptor antagonism/agonism can be uncoupled from pharmacoperone activity.Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growthMutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.Reproductive physiology of a humanized GnRH receptor mouse model: application in evaluation of human-specific analogs.GnRH Action
P2860
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P2860
Salt bridge integrates GPCR activation with protein trafficking
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Salt bridge integrates GPCR activation with protein trafficking
@ast
Salt bridge integrates GPCR activation with protein trafficking
@en
type
label
Salt bridge integrates GPCR activation with protein trafficking
@ast
Salt bridge integrates GPCR activation with protein trafficking
@en
prefLabel
Salt bridge integrates GPCR activation with protein trafficking
@ast
Salt bridge integrates GPCR activation with protein trafficking
@en
P2860
P356
P1476
Salt bridge integrates GPCR activation with protein trafficking
@en
P2093
Jo Ann Janovick
P Michael Conn
P2860
P304
P356
10.1073/PNAS.0914261107
P407
P577
2010-02-16T00:00:00Z