The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation
about
Small-molecule inhibition of BRDT for male contraception.Epigenetic regulation of the histone-to-protamine transition during spermiogenesisThe presence, role and clinical use of spermatozoal RNAsSperm nuclear proteome and its epigenetic potentialMouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesisRVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomainAcetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase InhibitorsThe Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous ProteinsInhibition of BET bromodomains as a therapeutic strategy for cancer drug discoveryBrd4 associates with mitotic chromosomes throughout early zebrafish embryogenesisMammalian sperm nuclear organization: resiliencies and vulnerabilitiesThe testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatidsInsights into role of bromodomain, testis-specific (Brdt) in acetylated histone H4-dependent chromatin remodeling in mammalian spermiogenesisBromodomain-dependent stage-specific male genome programming by BrdtIdentification of selective sweeps in closely related populations of the house mouse based on microsatellite scansIdentification of novel potent human testis-specific and bromodomain-containing protein (BRDT) inhibitors using crystal structure-based virtual screeningDrug Discovery Targeting Bromodomain-Containing Protein 4.Characterization of BRD4 during mammalian postmeiotic sperm development.The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target.The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo.Transcription and post-transcriptional regulation of spermatogenesis.Histone variant innovation in a rapidly evolving chordate lineage.Role of BRD4 in hematopoietic differentiation of embryonic stem cells.An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family.Protein acetylation and spermatogenesis.BET bromodomain inhibitors: a patent review.Sp1 transcription factor and GATA1 cis-acting elements modulate testis-specific expression of mouse cyclin A1Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.Two bromodomain proteins functionally interact to recapitulate an essential BRDT-like function in Drosophila spermatocytes.Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia.The bromodomain-containing gene BRD2 is regulated at transcription, splicing, and translation levels.3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.Contraception for men: a breakthrough new approachThe first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic backgroundBioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer.JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during SpermatogenesisBdf1 Bromodomains Are Essential for Meiosis and the Expression of Meiotic-Specific Genes.Histone acetylase inhibitor curcumin impairs mouse spermiogenesis-an in vitro study.The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility.
P2860
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P2860
The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation
description
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2007/10/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в жовтні 2007
@uk
مقالة علمية (نشرت في أكتوبر 2007)
@ar
name
The first bromodomain of Brdt, ...... male germ cell differentiation
@ast
The first bromodomain of Brdt, ...... male germ cell differentiation
@en
type
label
The first bromodomain of Brdt, ...... male germ cell differentiation
@ast
The first bromodomain of Brdt, ...... male germ cell differentiation
@en
prefLabel
The first bromodomain of Brdt, ...... male germ cell differentiation
@ast
The first bromodomain of Brdt, ...... male germ cell differentiation
@en
P2093
P3181
P356
P1433
P1476
The first bromodomain of Brdt, ...... male germ cell differentiation
@en
P2093
Debra J Wolgemuth
Duancheng Wen
Enyuan Shang
Xiangyuan Wang
P304
P3181
P356
10.1242/DEV.004481
P407
P577
2007-08-29T00:00:00Z