Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities
about
The replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationA network of multi-tasking proteins at the DNA replication fork preserves genome stabilityEvidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination.Genetic dissection of parallel sister-chromatid cohesion pathways.Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesionBreak-induced replication and telomerase-independent telomere maintenance require Pol32.The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes.A SUMO-like domain protein, Esc2, is required for genome integrity and sister chromatid cohesion in Saccharomyces cerevisiae.The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiaeMurine Pif1 interacts with telomerase and is dispensable for telomere function in vivoUnzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesionControl of Rad52 recombination activity by double-strand break-induced SUMO modification.Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase.Effects of mutations in SGS1 and in genes functionally related to SGS1 on inverted repeat-stimulated spontaneous unequal sister-chromatid exchange in yeastSgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes.Srs2: the "Odd-Job Man" in DNA repair.Regulation of fragile sites expression in budding yeast by MEC1, RRM3 and hydroxyurea.The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae.The amino terminus of the Saccharomyces cerevisiae DNA helicase Rrm3p modulates protein function altering replication and checkpoint activitySgs1 truncations induce genome rearrangements but suppress detrimental effects of BLM overexpression in Saccharomyces cerevisiae.Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.The absence of Top3 reveals an interaction between the Sgs1 and Pif1 DNA helicases in Saccharomyces cerevisiae.The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae.Break-induced replication requires DNA damage-induced phosphorylation of Pif1 and leads to telomere lengthening.Suppression of spontaneous genome rearrangements in yeast DNA helicase mutantsTop2 and Sgs1-Top3 Act Redundantly to Ensure rDNA Replication Termination.Human telomeres replicate using chromosome-specific, rather than universal, replication programs.Multiple Rad52-Mediated Homology-Directed Repair Mechanisms Are Required to Prevent Telomere Attrition-Induced Senescence in Saccharomyces cerevisiaeA Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression.Temporal separation of replication and recombination requires the intra-S checkpoint.A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination.Roles of Pif1-like helicases in the maintenance of genomic stability.RecQ helicases: lessons from model organisms.Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.Cell cycle regulation of DNA replication.Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3pTelomeres do the (un)twist: helicase actions at chromosome termini.Rrm3 protects the Saccharomyces cerevisiae genome from instability at nascent sites of retrotransposition
P2860
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P2860
Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities
description
2004 nî lūn-bûn
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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
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2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Saccharomyces cerevisiae Rrm3p ...... nt and fork restart activities
@ast
Saccharomyces cerevisiae Rrm3p ...... nt and fork restart activities
@en
type
label
Saccharomyces cerevisiae Rrm3p ...... nt and fork restart activities
@ast
Saccharomyces cerevisiae Rrm3p ...... nt and fork restart activities
@en
prefLabel
Saccharomyces cerevisiae Rrm3p ...... nt and fork restart activities
@ast
Saccharomyces cerevisiae Rrm3p ...... nt and fork restart activities
@en
P2860
P3181
P1476
Saccharomyces cerevisiae Rrm3p ...... nt and fork restart activities
@en
P2093
Sandra L Schnakenberg
Virginia A Zakian
P2860
P304
P3181
P356
10.1128/MCB.24.8.3198-3212.2004
P407
P577
2004-04-01T00:00:00Z