DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
about
The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcomeDNA replication stress: a source of APOBEC3B expression in breast cancerRisks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor HeterogeneityElevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.Treatment-Induced Mutagenesis and Selective Pressures Sculpt Cancer Evolution.Mutational Signatures in Breast Cancer: The Problem at the DNA LevelRoles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53.Assessment of an APOBEC3B truncating mutation, c.783delG, in patients with breast cancer.p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple CancersBeWith: A Between-Within method to discover relationships between cancer modules via integrated analysis of mutual exclusivity, co-occurrence and functional interactionsApolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like Gene Expression, RNA Editing, and MicroRNAs Regulation.Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B.Detecting presence of mutational signatures in cancer with confidence.Understanding the regulation of APOBEC3 expression: Current evidence and much to learn.APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution.Viral subversion of APOBEC3s: Lessons for anti-tumor immunity and tumor immunotherapy.Computational approaches for discovery of mutational signatures in cancer.APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response.Tumour heterogeneity and resistance to cancer therapies.APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.Correlation of gene expression and associated mutation profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with chemosensitivity of cancer cell lines to drug treatment.Onset of deaminase APOBEC3B induction in response to DNA double-strand breaksQ58714444APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression
P2860
Q33913152-57253C51-DC37-45B2-A8B0-21AB8CB7EFECQ34542213-52A057DE-BD63-467D-95C7-747DC79D8788Q37628288-02937F8B-B857-430B-B3D7-B0681ED93E7DQ38702556-310E7CD6-C468-4573-997F-DE206DDC51E7Q39176607-D68E733D-1319-4064-AEEB-6E2EE68EE36AQ39345007-0026C019-6DDD-4D3D-8E7D-52A4AB7474CEQ40076776-8F4F3200-A9E8-4B70-8795-C5A5C58E0BD0Q40319984-A726163B-B306-4384-B935-1B483E601FEAQ40381692-BD8F5BCE-49C9-4DD3-9881-2F969942B77EQ41924608-FD212DC9-9BBA-4ACF-A451-E5EDB5BB80EFQ42253948-48BB009B-D96C-4ACE-AC3C-92815F2BEBFAQ42375669-144DF110-3B46-4744-A544-55CF59B33938Q46748755-010BFE3F-ED0F-4ED6-AE8B-6D722543302EQ47152216-4A92401E-6A84-4AF7-A9E0-988EEC6D99B4Q47314376-BF754634-47FF-40F2-91A0-96DF82F0A2B7Q47552005-80897CF8-B08E-498A-A257-E09F936F8B62Q47555165-30F92ABE-0883-4801-81D2-A2B66580B42DQ47568875-E7B5ADF9-BBC0-4B1D-A6A0-3C089E69F3F7Q47664589-A9EC851E-045D-4996-9AEE-74421B75DE1EQ49725884-388D61B8-DA18-49BF-90FF-DDAF0DFC36D5Q50112440-91765324-E96A-4827-BF9B-6D32117D76DAQ50896511-A436BA3D-B953-4601-9E12-E8C95D01BDADQ52321974-778FD02E-4D5A-46C3-9278-3E5F3BC5934DQ52651787-58484F35-1EC2-4376-8DC2-835E343C18B7Q52719995-98BB113A-752C-4C80-B1EF-E86A945D29A4Q58703903-9B41395D-D7A6-498A-8A41-156B2CCE74E8Q58714444-0DA295C0-AED1-40C4-93F4-3A48E8953320Q58764658-A49DA5A5-2258-4F80-B884-B09ABA6354BD
P2860
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
description
2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
@ast
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
@en
type
label
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
@ast
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
@en
prefLabel
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
@ast
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
@en
P2093
P2860
P50
P3181
P1433
P1476
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
@en
P2093
Emily K Law
Gerald Goh
Maik Kschischo
Maria Antonietta Cerone
Michael I Walton
Michelle Dietzen
Nnennaya Kanu
Olivia W Rossanese
Rebecca Rogers
Subramanian Venkatesan
P2860
P2888
P3181
P356
10.1186/S13059-016-1042-9
P407
P50
P577
2016-09-15T00:00:00Z
P6179
1001918995