APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication
about
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancerSelf-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damageCrystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulationMutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair.Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli.APOBEC3A damages the cellular genome during DNA replicationFunctional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses.When Genome Maintenance Goes Badly Awry.Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor HeterogeneityCytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.APOBEC3A associates with human papillomavirus genome integration in oropharyngeal cancers.Understanding mutagenesis through delineation of mutational signatures in human cancer.POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologiesAPOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast.Functions and Malfunctions of Mammalian DNA-Cytosine DeaminasesAPOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context.Mutational Signatures in Breast Cancer: The Problem at the DNA LevelRoles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.Clonal evolution of chemotherapy-resistant urothelial carcinoma.Avoidance of APOBEC3B-induced mutation by error-free lesion bypassEnzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B.Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases.Short inverted repeats contribute to localized mutability in human somatic cells.Transcribing malignancy: transcription-associated genomic instability in cancer.APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition.Within-Host Variations of Human Papillomavirus Reveal APOBEC-Signature Mutagenesis in the Viral Genome.The rabbit as an orthologous small animal model for APOBEC3A oncogenesis.Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation.Onset of deaminase APOBEC3B induction in response to DNA double-strand breaksMutational signature distribution varies with DNA replication timing and strand asymmetryAPOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 ExpressionStrategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity
P2860
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P2860
APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
APOBEC3A and APOBEC3B Preferen ...... emplate during DNA Replication
@ast
APOBEC3A and APOBEC3B Preferen ...... emplate during DNA Replication
@en
APOBEC3A and APOBEC3B Preferen ...... emplate during DNA Replication
@nl
type
label
APOBEC3A and APOBEC3B Preferen ...... emplate during DNA Replication
@ast
APOBEC3A and APOBEC3B Preferen ...... emplate during DNA Replication
@en
APOBEC3A and APOBEC3B Preferen ...... emplate during DNA Replication
@nl
prefLabel
APOBEC3A and APOBEC3B Preferen ...... emplate during DNA Replication
@ast
APOBEC3A and APOBEC3B Preferen ...... emplate during DNA Replication
@en
APOBEC3A and APOBEC3B Preferen ...... emplate during DNA Replication
@nl
P2093
P2860
P50
P3181
P1433
P1476
APOBEC3A and APOBEC3B Preferen ...... emplate during DNA Replication
@en
P2093
James I Hoopes
Steven A Roberts
Tony M Mertz
P2860
P304
P3181
P356
10.1016/J.CELREP.2016.01.021
P407
P577
2016-01-28T00:00:00Z