PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling
about
Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human diseasePI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infectionInhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice.Identification of inhibitors of inositol 5-phosphatases through multiple screening strategies.Attacking the supply wagons to starve cancer cells to death.Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression.Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.Small-molecule control of cytokine function: new opportunities for treating immune disordersDetection and manipulation of phosphoinositides.Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activityPlentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).Early to Late Endosome Trafficking Controls Secretion and Zymogen Activation in Rodent and Human Pancreatic Acinar Cells.APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complexPI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes.Biallelic Mutations of VAC14 in Pediatric-Onset Neurological Disease.Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity.PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.PIKfyve inhibition increases exosome release and induces secretory autophagy.Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.The IL-17-Th1/Th17 pathway: an attractive target for lung cancer therapy?PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.Microbe-inducible trafficking pathways that control Toll-like receptor signaling.PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides.The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma.Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages.PIKfyve regulates melanosome biogenesis.Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence.Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.Emerging Mechanisms of Innate Immunity and Their Translational Potential in Inflammatory Bowel Disease.The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells.Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation
P2860
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P2860
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
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2013年论文
@wuu
name
PIKfyve, a class III PI kinase ...... n Toll-like receptor signaling
@ast
PIKfyve, a class III PI kinase ...... n Toll-like receptor signaling
@en
type
label
PIKfyve, a class III PI kinase ...... n Toll-like receptor signaling
@ast
PIKfyve, a class III PI kinase ...... n Toll-like receptor signaling
@en
prefLabel
PIKfyve, a class III PI kinase ...... n Toll-like receptor signaling
@ast
PIKfyve, a class III PI kinase ...... n Toll-like receptor signaling
@en
P2093
P2860
P921
P3181
P1476
PIKfyve, a class III PI kinase ...... n Toll-like receptor signaling
@en
P2093
Abel Alcázar-Román
Aleem N Fazal
Andreas Billich
Atwood K Cheung
Bailin Zhang
Christopher J Wilson
Daniel Baird
Gerard Joberty
Hidde L Ploegh
Jean-Michel Rondeau
P2860
P304
P3181
P356
10.1016/J.CHEMBIOL.2013.05.010
P407
P577
2013-07-25T00:00:00Z