A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.
about
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibitionPI(5)P regulates autophagosome biogenesisRac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria.The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphologyKinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furinDecreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretaseFunctional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- miceInhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella.PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasisArabidopsis FAB1/PIKfyve proteins are essential for development of viable pollenArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionalityPhosphatidylinositol 3,5-bisphosphate: low abundance, high significanceInositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human diseaseEndosome maturationPhosphoinositides: tiny lipids with giant impact on cell regulationLipid kinases as therapeutic targets for chronic painPhosphoinositides in the mammalian endo-lysosomal networkThe Amyloid Precursor Protein Controls PIKfyve FunctionPI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complexThe Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell deathA selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiationTargeting TRPM2 in ROS-Coupled DiseasesGenetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathiesThe PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cellsThe ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in CellsPIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signalingThe phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infectionGenetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection.Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell deathSeptins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion.Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis.Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain.AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyveInhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice.At the crossroads of chemistry and cell biology: inhibiting membrane traffic by small molecules.
P2860
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P2860
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A selective PIKfyve inhibitor ...... ansport and retroviral budding
@nl
A selective PIKfyve inhibitor ...... nsport and retroviral budding.
@ast
A selective PIKfyve inhibitor ...... nsport and retroviral budding.
@en
A selective PIKfyve inhibitor ...... nsport and retroviral budding.
@en-gb
type
label
A selective PIKfyve inhibitor ...... ansport and retroviral budding
@nl
A selective PIKfyve inhibitor ...... nsport and retroviral budding.
@ast
A selective PIKfyve inhibitor ...... nsport and retroviral budding.
@en
A selective PIKfyve inhibitor ...... nsport and retroviral budding.
@en-gb
prefLabel
A selective PIKfyve inhibitor ...... ansport and retroviral budding
@nl
A selective PIKfyve inhibitor ...... nsport and retroviral budding.
@ast
A selective PIKfyve inhibitor ...... nsport and retroviral budding.
@en
A selective PIKfyve inhibitor ...... nsport and retroviral budding.
@en-gb
P2093
P2860
P3181
P356
P1433
P1476
A selective PIKfyve inhibitor ...... nsport and retroviral budding.
@en
P2093
Christine Boucheron
Frank T Cooke
Harold B J Jefferies
Hiroyuki Kaizawa
Masahiko Hayakawa
Michael D Waterfield
Parmjit Jat
Takahide Ohishi
Tomonobu Koizumi
P2860
P304
P3181
P356
10.1038/SJ.EMBOR.7401155
P407
P577
2008-01-11T00:00:00Z