Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion
about
How special is the biochemical function of native proteins?Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding AffinitiesStructural basis of integrin regulation and signalingOn the role of physics and evolution in dictating protein structure and functionStructure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.Computational design of antibody-affinity improvement beyond in vivo maturationThe protein-protein interface evolution acts in a similar way to antibody affinity maturation.Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function.Anchored design of protein-protein interfaces.Interplay of physics and evolution in the likely origin of protein biochemical functionApplying physics-based scoring to calculate free energies of binding for single amino acid mutations in protein-protein complexesImportance of force linkage in mechanochemistry of adhesion receptors.The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrinsRegulation of integrin affinity on cell surfacesProgress in computational protein design.Force spectroscopy of LFA-1 and its ligands, ICAM-1 and ICAM-2.Expanded explorations into the optimization of an energy function for protein design.Computer-aided design of functional protein interactions.Triathlon for energy functions: who is the winner for design of protein-protein interactions?Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.Increasing affinity of interferon-γ receptor 1 to interferon-γ by computer-aided design.Mutations designed to destabilize the receptor-bound conformation increase MICA-NKG2D association rate and affinity.Ligand- and cation-induced structural alterations of the leukocyte integrin LFA-1.
P2860
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P2860
Rational design of intercellular adhesion molecule-1 (ICAM-1) variants for antagonizing integrin lymphocyte function-associated antigen-1-dependent adhesion
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Rational design of intercellul ...... d antigen-1-dependent adhesion
@ast
Rational design of intercellul ...... d antigen-1-dependent adhesion
@en
type
label
Rational design of intercellul ...... d antigen-1-dependent adhesion
@ast
Rational design of intercellul ...... d antigen-1-dependent adhesion
@en
prefLabel
Rational design of intercellul ...... d antigen-1-dependent adhesion
@ast
Rational design of intercellul ...... d antigen-1-dependent adhesion
@en
P2093
P2860
P356
P1476
Rational design of intercellul ...... d antigen-1-dependent adhesion
@en
P2093
David Baker
Greg A Lazar
John R Desjarlais
Motomu Shimaoka
Timothy A Springer
P2860
P304
P356
10.1074/JBC.M510454200
P407
P577
2006-02-24T00:00:00Z