CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium
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Nebuliser systems for drug delivery in cystic fibrosisAnimal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and DivergencesNew and emerging targeted therapies for cystic fibrosisPharmacological chaperoning: a primer on mechanism and pharmacologyIntegrin α6β4 identifies human distal lung epithelial progenitor cells with potential as a cell-based therapy for cystic fibrosis lung diseaseCurrent and Emerging Therapies for the Treatment of Cystic Fibrosis or Mitigation of Its SymptomsBarriers to inhaled gene therapy of obstructive lung diseases: A reviewThe Role of Human Parainfluenza Virus Infections in the Immunopathology of the Respiratory Tract.RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction.Continuous mucociliary transport by primary human airway epithelial cells in vitro.Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.Growth restriction of an experimental live attenuated human parainfluenza virus type 2 vaccine in human ciliated airway epithelium in vitro parallels attenuation in African green monkeys.Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftorCystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis.Respiratory syncytial virus engineered to express the cystic fibrosis transmembrane conductance regulator corrects the bioelectric phenotype of human cystic fibrosis airway epithelium in vitro.Is CFTR-delF508 really absent from the apical membrane of the airway epithelium?Lysophosphatidylcholine as an adjuvant for lentiviral vector mediated gene transfer to airway epithelium: effect of acyl chain length.Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium.Use of kinase inhibitors to correct ΔF508-CFTR function.Correction of defective CFTR/ENaC function and tightness of cystic fibrosis airway epithelium by amniotic mesenchymal stromal (stem) cells.α-Fetoprotein gene delivery to the nasal epithelium of nonhuman primates by human parainfluenza viral vectorsA functional anatomic defect of the cystic fibrosis airway.Nanotechnology approaches for inhalation treatment of fibrosis.Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis.Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteineImprovement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells.Efficient intratracheal delivery of airway epithelial cells in mice and pigsComparison of differing cytopathic effects in human airway epithelium of parainfluenza virus 5 (W3A), parainfluenza virus type 3, and respiratory syncytial virus.N-acetylcysteine enhances cystic fibrosis sputum penetration and airway gene transfer by highly compacted DNA nanoparticles.RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR.Automated acquisition and analysis of airway surface liquid height by confocal microscopyCystic Fibrosis Gene Therapy in the UK and Elsewhere.Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly-L-lysine.Arsenic promotes ubiquitinylation and lysosomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels in human airway epithelial cellsAdvances in cell and gene-based therapies for cystic fibrosis lung diseaseSuppression of premature termination codons as a therapeutic approach.Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells.The cystic-fibrosis-associated ΔF508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3.Lentiviral vector gene transfer to porcine airways.
P2860
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P2860
CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium
description
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im Juli 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2009/07/01)
@nl
наукова стаття, опублікована в липні 2009
@uk
مقالة علمية (نشرت في يوليو 2009)
@ar
name
CFTR delivery to 25% of surfac ...... tic fibrosis airway epithelium
@ast
CFTR delivery to 25% of surfac ...... tic fibrosis airway epithelium
@en
type
label
CFTR delivery to 25% of surfac ...... tic fibrosis airway epithelium
@ast
CFTR delivery to 25% of surfac ...... tic fibrosis airway epithelium
@en
prefLabel
CFTR delivery to 25% of surfac ...... tic fibrosis airway epithelium
@ast
CFTR delivery to 25% of surfac ...... tic fibrosis airway epithelium
@en
P2093
P2860
P921
P3181
P1433
P1476
CFTR delivery to 25% of surfac ...... tic fibrosis airway epithelium
@en
P2093
April Mengos
Brian Button
Leatrice N. Vogel
Liqun Zhang
Mario H. Skiadopoulos
Peter L. Collins
Raymond J. Pickles
Richard C. Boucher
Sherif E. Gabriel
Susan Burkett
P2860
P304
P3181
P356
10.1371/JOURNAL.PBIO.1000155
P407
P577
2009-07-01T00:00:00Z