Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis - Wikidata - awgldk - TriplyDB

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

http://www.wikidata.org/entity/Q29013419

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Next-generation antimicrobials: from chemical biology to first-in-class drugs Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense Identification of KasA as the cellular target of an anti-tubercular scaffold Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens.Validation of a High-Throughput Screening Assay for Identification of Adjunctive and Directly Acting Antimicrobials Targeting Carbapenem-Resistant Enterobacteriaceae.SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses.A chemical screen to identify inducers of the mitochondrial unfolded protein response in C. elegans.Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms Docking into Mycobacterium tuberculosis Thioredoxin Reductase Protein Yields Pyrazolone Lead Molecules for Methicillin-Resistant Staphylococcus aureus Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway Leishmania donovani Encodes a Functional Selenocysteinyl-tRNA Synthase.Auranofin-loaded nanoparticles as a new therapeutic tool to fight streptococcal infections.Repurposing auranofin for the treatment of cutaneous staphylococcal infections.X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria.Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent.Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.Drug repurposing screens and synergistic drug-combinations for infectious diseases.Mononuclear gold(iii) complexes with l-histidine-containing dipeptides: tuning the structural and biological properties by variation of the N-terminal amino acid and counter anion.The trials and tribulations of repurposing metformin and other generic drugs for tuberculosis.Drug repurposing: a new front in the war against Staphylococcus aureus.Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin.Targeting Phenotypically Tolerant Mycobacterium tuberculosis.Diphenyleneiodonium chloride (DPIC) displays broad-spectrum bactericidal activity.Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections.Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects.Histone Methyltransferase SET8 Epigenetically Reprograms Host Immune Responses to Assist Mycobacterial Survival.Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics.Better living through chemistry: Addressing emerging antibiotic resistance.Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors.Developmental toxicity of auranofin in zebrafish embryos.Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System.Extensive impact of non-antibiotic drugs on human gut bacteria.Evidence for Inhibition of Topoisomerase 1A by Gold(III) Macrocycles and Chelates Targeting Mycobacterium tuberculosis and Mycobacterium abscessus.Targeting the Proteostasis Network for Mycobacterial Drug Discovery.Auranofin and N-heterocyclic carbene gold-analogs are potent inhibitors of the bacteria Helicobacter pylori.Repurposing auranofin as an intestinal decolonizing agent for vancomycin-resistant enterococci.Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum Evaluating New Compounds to Treat Infections Antimicrobial and Antibiofilm Activity of Synergistic Combinations of a Commercially Available Small Compound Library With Colistin Against

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Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis

http://www.wikidata.org/entity/Q29013419

description

2015 nî lūn-bûn

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2015 թուականի Մարտին հրատարակուած գիտական յօդուած

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2015 թվականի մարտին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Auranofin exerts broad-spectru ...... geting thiol-redox homeostasis

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Auranofin exerts broad-spectru ...... geting thiol-redox homeostasis

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type

label

Auranofin exerts broad-spectru ...... geting thiol-redox homeostasis

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Auranofin exerts broad-spectru ...... geting thiol-redox homeostasis

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Auranofin exerts broad-spectru ...... geting thiol-redox homeostasis

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Auranofin exerts broad-spectru ...... geting thiol-redox homeostasis

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PNAS.1504022112

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Proceedings of the National Academy of Sciences of the United States of America

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Auranofin exerts broad-spectru ...... geting thiol-redox homeostasis

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Arnab K Chatterjee

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Baiyuan Yang

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Catherine Vilchèze

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Mary E Hensler

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Michael B Harbut

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Peter G Schultz

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P2860

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

The complete genome sequence of the gastric pathogen Helicobacter pylori

Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli

Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects

The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

Genes required for mycobacterial growth defined by high density mutagenesis

Auranofin versus placebo in rheumatoid arthritis

Gold compound auranofin inhibits IkappaB kinase (IKK) by modifying Cys-179 of IKKbeta subunit

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4453-4458

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scholarly article

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10.1073/PNAS.1504022112

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25831516

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4394260

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