about
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosisExploring the mycobacteriophage metaproteome: phage genomics as an educational platformEfficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integraseSulfite reduction in mycobacteriaMechanism of thioamide drug action against tuberculosis and leprosyMalaria infections do not compromise vaccine-induced immunity against tuberculosis in miceStructure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosisStructural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductaseTargeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural dataCrystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPaseCrystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesisCrystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation responseStructure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosisThe Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial ParasitesTriclosan Derivatives: Towards Potent Inhibitors of Drug-Sensitive and Drug-ResistantMycobacterium tuberculosisPhosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosisIdentification of a small molecule with activity against drug-resistant and persistent tuberculosisCrystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicingPyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosisOrigins of highly mosaic mycobacteriophage genomesThe Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug developmentCloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutationsNADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatisTranscriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosisFluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosisOleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic targetTwo polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosisIdentification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screeningProtection elicited by two glutamine auxotrophs of Mycobacterium tuberculosis and in vivo growth phenotypes of the four unique glutamine synthetase mutants in a murine modelDeletion of the Mycobacterium tuberculosis resuscitation-promoting factor Rv1009 gene results in delayed reactivation from chronic tuberculosisThe Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetaseProtein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infectionMutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complexThe Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutolComplex lipid determines tissue-specific replication of Mycobacterium tuberculosis in miceA novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosisIsolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteriaAttenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosisMycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulenceThe alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis
P50
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P50
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Forscher
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researcher
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W R Jacobs
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W R Jacobs
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W R Jacobs
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W R Jacobs
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W R Jacobs
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W R Jacobs
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W R Jacobs
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W R Jacobs
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W R Jacobs
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W R Jacobs
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W R Jacobs
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W R Jacobs
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P108
P31
P496
0000-0003-3321-3080