Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins
about
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membraneSTIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channelsCalcium signaling in mammalian egg activation and embryo development: the influence of subcellular localizationHuman muscle economy myoblast differentiation and excitation-contraction coupling use the same molecular partners, STIM1 and STIM2STIM1, an essential and conserved component of store-operated Ca2+ channel functionSTIM and Orai1 Variants in Store-Operated Calcium EntrySTIM and ORAI proteins in the nervous systemStructural aspects of calcium-release activated calcium channel functionMolecular regulation of CRAC channels and their role in lymphocyte functionMapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activationSTIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channelsDi-arginine signals and the K-rich domain retain the Ca²⁺ sensor STIM1 in the endoplasmic reticulumInitial activation of STIM1, the regulator of store-operated calcium entryStromal interaction molecule (STIM) 1 and STIM2 calcium sensing regions exhibit distinct unfolding and oligomerization kineticsNative STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neuronsStore-operated calcium entry promotes the degradation of the transcription factor Sp4 in resting neurons.A dominant STIM1 mutation causes Stormorken syndrome.Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domainSTIM and Orai isoform expression in pregnant human myometrium: a potential role in calcium signaling during pregnancy.A human sterile alpha motif domain polymerizome.A STIM2 splice variant negatively regulates store-operated calcium entry.Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channelsLive-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.Regulation of store-operated calcium entry during cell division.Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis.Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension.Novel compartment implicated in calcium signaling--is it an "induced coupling domain"?Orais and STIMs: physiological mechanisms and diseaseBombyx mori homologs of STIM1 and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.Partial unfolding and oligomerization of stromal interaction molecules as an initiation mechanism of store operated calcium entry.SOC and now also SIC: store-operated and store-inhibited channels.Immunodeficiency due to defects in store-operated calcium entry.Unraveling STIM2 function.Voltage gating at the selectivity filter of the Ca2+ release-activated Ca2+ channel induced by mutation of the Orai1 protein.Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site.Identification of functional domains and novel binding partners of STIM proteins.Location and function of STIM1 in the activation of Ca2+ entry signals.Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels.STIM1 and STIM2 proteins differently regulate endogenous store-operated channels in HEK293 cells.A cytosolic STIM2 preprotein created by signal peptide inefficiency activates ORAI1 in a store-independent manner.
P2860
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P2860
Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification and characteriz ...... lass of transmembrane proteins
@ast
Identification and characteriz ...... lass of transmembrane proteins
@en
type
label
Identification and characteriz ...... lass of transmembrane proteins
@ast
Identification and characteriz ...... lass of transmembrane proteins
@en
prefLabel
Identification and characteriz ...... lass of transmembrane proteins
@ast
Identification and characteriz ...... lass of transmembrane proteins
@en
P2093
P1433
P1476
Identification and characteriz ...... lass of transmembrane proteins
@en
P2093
Janette S. KAZENWADEL
Jean-Pierre EID
Leonie VAN STEKELENBURG
Manuela S. HANCOCK
Marie A. DZIADEK
Nigel J. PARKER
Paul V. SENIOR
Peter J. SMITH
Richard T. WILLIAMS
Robert SAINT
P356
10.1042/0264-6021:3570673
P407
P577
2001-08-01T00:00:00Z