Systematic identification of genomic markers of drug sensitivity in cancer cells - Wikidata - awgldk - TriplyDB

Systematic identification of genomic markers of drug sensitivity in cancer cells

Systematic identification of genomic markers of drug sensitivity in cancer cells

http://www.wikidata.org/entity/Q29547695

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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines Cancer vulnerabilities unveiled by genomic loss Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents Drugging MYCN through an allosteric transition in Aurora kinase A MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models Integrative cancer epidemiology--the next generation The Cancer Genome Atlas Pan-Cancer analysis project DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs Effects of Charged Particles on Human Tumor Cells Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine Preclinical Childhood Sarcoma Models: Drug Efficacy Biomarker Identification and Validation Fifteen years of irinotecan therapy for pediatric sarcoma: where to next?The Tumor Macroenvironment: Cancer-Promoting Networks Beyond Tumor Beds Cancer Cell Line Panels Empower Genomics-Based Discovery of Precision Cancer Medicine Predictive biomarkers in precision medicine and drug development against lung cancer Targeting melanoma by small molecules: challenges ahead Using CellMiner 1.6 for Systems Pharmacology and Genomic Analysis of the NCI-60 Evolution and dynamics of pancreatic cancer progression Beyond Breast and Ovarian Cancers: PARP Inhibitors for BRCA Mutation-Associated and BRCA-Like Solid Tumors From integrative genomics to therapeutic targets Systems biology of cisplatin resistance: past, present and future RB1: a prototype tumor suppressor and an enigma Synthetic lethality and cancer: cohesin and PARP at the replication fork Drugging topoisomerases: lessons and challenges In vitro human cell line models to predict clinical response to anticancer drugs In vitro and in vivo models for analysis of resistance to anticancer molecular therapies Apoptotic agents Prospects and pitfalls of personalizing therapies for sarcomas: from children, adolescents, and young adults to the elderly Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis.Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment Using drug response data to identify molecular effectors, and molecular "omic" data to identify candidate drugs in cancer Assay Establishment and Validation of a High-Throughput Screening Platform for Three-Dimensional Patient-Derived Colon Cancer Organoid Cultures Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.Advances in targeting signal transduction pathways Cancer genome sequencing: understanding malignancy as a disease of the genome, its conformation, and its evolution.A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors.UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib.

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P2860

Systematic identification of genomic markers of drug sensitivity in cancer cells

http://www.wikidata.org/entity/Q29547695

description

2012 nî lūn-bûn

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2012 թուականի Մարտին հրատարակուած գիտական յօդուած

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2012 թվականի մարտին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Systematic identification of genomic markers of drug sensitivity in cancer cells

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Systematic identification of genomic markers of drug sensitivity in cancer cells

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Systematic identification of genomic markers of drug sensitivity in cancer cells

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Systematic identification of genomic markers of drug sensitivity in cancer cells

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Barthorpe S

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Baselga J

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Benes CH

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Dastur A

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Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer

Cytoscape: a software environment for integrated models of biomolecular interaction networks

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation.

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.

Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer.

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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570-5

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10.1038/NATURE11005

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