Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
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PINK1 is selectively stabilized on impaired mitochondria to activate ParkinThe phosphorylation-dependent regulation of mitochondrial proteins in stress responsesParkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondriaSleep and brain energy levels: ATP changes during sleepParkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65Ubiquitin is phosphorylated by PINK1 to activate parkinPINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motilityPARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neuronsThe mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagyMUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkinPINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagyMitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cellsIdentification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screenMitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagyShort mitochondrial ARF triggers Parkin/PINK1-dependent mitophagyPhosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neuronsCLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteinsBiochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)The role of oxidative stress in Parkinson's diseasePINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradationRNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathwaysPhosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signalingInactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagyParkin is recruited selectively to impaired mitochondria and promotes their autophagyHexokinase activity is required for recruitment of parkin to depolarized mitochondriaLoss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fissionThe kinase domain of mitochondrial PINK1 faces the cytoplasmGenome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagyPINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsLoss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxiaBroad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagyStructure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionPGC-1α, a potential therapeutic target for early intervention in Parkinson's diseaseOxidative stress, mitochondrial dysfunction, and agingMitochondria, calcium and cell death: a deadly triad in neurodegenerationMitochondrial dysfunction in Parkinson's diseaseParkinson's Disease: The Mitochondria-Iron LinkNeuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent Perspectives
P2860
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P2860
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
@ast
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
@en
type
label
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
@ast
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
@en
prefLabel
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
@ast
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
@en
P2093
P3181
P356
P1433
P1476
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
@en
P2093
Eunkyung Bae
Jaeseob Kim
Jeehye Park
Jin-Man Kim
Jongkyeong Chung
Saera Song
Sung Bae Lee
Sungkyu Lee
Sunhong Kim
Yongsung Kim
P2888
P304
P356
10.1038/NATURE04788
P407
P50
P577
2006-05-03T00:00:00Z
P5875
P6179
1012088074