Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
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A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptorSystematic identification of regulatory proteins critical for T-cell activationDevelopment of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints.Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysisImmunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysisFHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1Crystal structure of a lipid G protein-coupled receptorPTEN as an effector in the signaling of antimigratory G protein-coupled receptorThe role of sphingosine-1-phosphate transporter Spns2 in immune system functionActions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in miceSphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and functionDiscovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotypeFTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacologyFull pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactionsS1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egressTargeting protein serine/threonine phosphatases for drug developmentTug of war at the exit doorA central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egressThe immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptorsEmerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinomaFingolimod in the treatment of relapsing-remitting multiple sclerosis: long-term experience and an update on the clinical evidenceSphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic PotentialRole of Sphingolipids in the Pathobiology of Lung InflammationHDL-S1P: cardiovascular functions, disease-associated alterations, and therapeutic applicationsLymphatic disorders after renal transplantation: new insights for an old complicationOptimizing therapeutics in the management of patients with multiple sclerosis: a review of drug efficacy, dosing, and mechanisms of actionIntegrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactionsAdvancing Biological Understanding and Therapeutics Discovery with Small-Molecule ProbesThe mTOR pathway and integrating immune regulationSphingosine-1-phosphate in chronic intestinal inflammation and cancerSphingosine 1-phosphate signallingLysophospholipids and their receptors in the central nervous systemThe actin-bundling protein L-plastin supports T-cell motility and activationRevisiting the sphingolipid rheostat: Evolving concepts in cancer therapySphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progressEndogenous lipid activated G protein-coupled receptors: emerging structural features from crystallography and molecular dynamics simulationsFingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapySphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyondFingolimod for the treatment of neurological diseases-state of play and future perspectivesPeripheral Leukocyte Migration in Ferrets in Response to Infection with Seasonal Influenza Virus
P2860
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P2860
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
description
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 2002
@ast
im April 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 12 April 2002)
@en
wetenschappelijk artikel (gepubliceerd op 2002/04/12)
@nl
наукова стаття, опублікована у квітні 2002
@uk
مقالة علمية (نشرت في 12-4-2002)
@ar
name
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
@ast
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
@en
type
label
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
@ast
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
@en
prefLabel
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
@ast
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
@en
P2093
P3181
P356
P1433
P1476
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
@en
P2093
Bergstrom J
Milligan J
Quackenbush E
P3181
P356
10.1126/SCIENCE.1070238
P407
P577
2002-04-12T00:00:00Z