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The antioxidant function of the p53 tumor suppressor

The antioxidant function of the p53 tumor suppressor

http://www.wikidata.org/entity/Q29619231

about

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3 Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria p53 opens the mitochondrial permeability transition pore to trigger necrosis Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells Does Nrf2 contribute to p53-mediated control of cell survival and death?Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing Modulation of intracellular ROS levels by TIGAR controls autophagy Redox-directed cancer therapeutics: molecular mechanisms and opportunities The first 30 years of p53: growing ever more complex The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity Two faces of p53: aging and tumor suppression Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy Clinical significance of T cell metabolic reprogramming in cancer Metabolic, autophagic, and mitophagic activities in cancer initiation and progression Cancer drug resistance: redox resetting renders a way Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function Potential Modulation of Sirtuins by Oxidative Stress Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results Redox Regulation in Cancer Stem Cells Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease Reactive oxygen species in health and disease Axis of ageing: telomeres, p53 and mitochondria Alcohol, insulin resistance and the liver-brain axis Tumor suppressor p53 and its gain-of-function mutants in cancer Role of the p53 tumor suppressor in metabolism ARTD1 (PARP1) activation and NAD(+) in DNA repair and cell death The role of tumor suppressor p53 in the antioxidant defense and metabolism Involvement of free radicals in breast cancer Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutants Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains Hepatoprotective role of Sestrin2 against chronic ER stress Sestrins inhibit mTORC1 kinase activation through the GATOR complex p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling Linking functional decline of telomeres, mitochondria and stem cells during ageing

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P2860

The antioxidant function of the p53 tumor suppressor

http://www.wikidata.org/entity/Q29619231

description

2005 nî lūn-bûn

@nan

2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

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2005年論文

@zh-tw

2005年论文

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name

The antioxidant function of the p53 tumor suppressor

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The antioxidant function of the p53 tumor suppressor

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type

label

The antioxidant function of the p53 tumor suppressor

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The antioxidant function of the p53 tumor suppressor

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prefLabel

The antioxidant function of the p53 tumor suppressor

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The antioxidant function of the p53 tumor suppressor

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Nature Medicine

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The antioxidant function of the p53 tumor suppressor

@en

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Galina V Ilyinskaya

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Julia E Kravchenko

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Larissa S Agapova

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P2860

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

Oxidative Decay of DNA

A model for p53-induced apoptosis

Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

Free radicals in the physiological control of cell function

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

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10.1038/NM1320

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12

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11

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Peter M. Chumakov

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2005-11-13T00:00:00Z

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7481368

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16286925

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2637821

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