about
Hepatitis A virus and the origins of picornaviruses.Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes.Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In VitroSubstrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiationEquine Rhinitis A Virus and Its Low pH Empty Particle: Clues Towards an Aphthovirus Entry Mechanism?Crystal structure of equine rhinitis A virus in complex with its sialic acid receptorA sensor-adaptor mechanism for enterovirus uncoating from structures of EV71Picornavirus uncoating intermediate captured in atomic detailStructure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion releaseMore-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding moleculesLimits of Structural Plasticity in a Picornavirus Capsid Revealed by a Massively Expanded Equine Rhinitis A Virus ParticleCapsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric poreInhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system.Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus productionHepatitis B small surface antigen particles are octahedral.Characterization of early steps in the poliovirus infection process: receptor-decorated liposomes induce conversion of the virus to membrane-anchored entry-intermediate particles.NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system.Revealing the density of encoded functions in a viral RNAEmploying transposon mutagenesis to investigate foot-and-mouth disease virus replication.Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranesPotent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16.Increasing Type 1 Poliovirus Capsid Stability by Thermal Selection.Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus.Inhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers.Formation of higher-order foot-and-mouth disease virus 3D(pol) complexes is dependent on elongation activityBoth cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.Expression of hepatitis C virus (HCV) structural proteins in trans facilitates encapsidation and transmission of HCV subgenomic RNA.Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo.Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel.Discrimination among rhinovirus serotypes for a variant ICAM-1 receptor molecule.Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine.Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro.Tagging of NS5A expressed from a functional hepatitis C virus replicon.A link between translation of the hepatitis C virus polyprotein and polymerase function; possible consequences for hyperphosphorylation of NS5A.A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria.Introduction of replication-competent hepatitis C virus transcripts using a tetracycline-regulable baculovirus delivery system.Mouse respiratory epithelial cells support efficient replication of human rhinovirus.Cell entry of the aphthovirus equine rhinitis A virus is dependent on endosome acidification.Picornaviruses.FMDV replicons encoding green fluorescent protein are replication competent.
P50
Mathematical Virology: A new mathematical approach to viral evolution grounded in experimentThe roles of the pre-genomic RNA in Hepatitis B Virus nucleocapsid assembly.Single-molecule assays of the assembly/disassembly mechanisms of ssRNA viruses - Tools for screening novel anti-viralsDissection of the interactions involved in replication of foot and mouth disease virus using RNA aptamers
P710
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P50
description
researcher
@en-gb
veterinary virologist
@en
wetenschapper
@nl
name
David J Rowlands
@sl
David Rowlands
@af
David Rowlands
@an
David Rowlands
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David Rowlands
@ay
David Rowlands
@az
David Rowlands
@br
David Rowlands
@ca
David Rowlands
@ce
David Rowlands
@ceb
type
label
David J Rowlands
@sl
David Rowlands
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David Rowlands
@an
David Rowlands
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David Rowlands
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David Rowlands
@az
David Rowlands
@br
David Rowlands
@ca
David Rowlands
@ce
David Rowlands
@ceb
altLabel
David J Rowlands
@en
David J Rowlands
@en-gb
David J Rowlands
@nl
David J. Rowlands
@af
David J. Rowlands
@an
David J. Rowlands
@ast
David J. Rowlands
@ay
David J. Rowlands
@az
David J. Rowlands
@br
David J. Rowlands
@ca
prefLabel
David J Rowlands
@sl
David Rowlands
@af
David Rowlands
@an
David Rowlands
@ast
David Rowlands
@ay
David Rowlands
@az
David Rowlands
@br
David Rowlands
@ca
David Rowlands
@ce
David Rowlands
@ceb
P1344
P1006
P214
P6366
P1006
P106
P1153
7103109103
P1344
P2031
1969-01-01T00:00:00Z
P21
P214
P31
P3885
david-rowlands
P496
0000-0002-4742-9272
P569
1940-01-01T00:00:00Z
P6178
0672233670.67
P6366
2160363910