Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes
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Oligodendroglial membrane dynamics in relation to myelin biogenesisMyelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoformsDocking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP)-Insights into a noncanonical and fuzzy interaction.The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro.Interaction of myelin basic protein with cytoskeletal and signaling proteins in cultured primary oligodendrocytes and N19 oligodendroglial cells.The effects of threonine phosphorylation on the stability and dynamics of the central molecular switch region of 18.5-kDa myelin basic protein.The 21.5-kDa isoform of myelin basic protein has a non-traditional PY-nuclear-localization signalClassic 18.5- and 21.5-kDa myelin basic protein isoforms associate with cytoskeletal and SH3-domain proteins in the immortalized N19-oligodendroglial cell line stimulated by phorbol ester and IGF-1.Glatiramer acetate and nanny proteins restrict access of the multiple sclerosis autoantigen myelin basic protein to the 26S proteasomeStructured functional domains of myelin basic protein: cross talk between actin polymerization and Ca(2+)-dependent calmodulin interactionNucleus-localized 21.5-kDa myelin basic protein promotes oligodendrocyte proliferation and enhances neurite outgrowth in coculture, unlike the plasma membrane-associated 18.5-kDa isoformMaking myelin basic protein -from mRNA transport to localized translation.Fyn in Neurodevelopment and Ischemic Brain Injury.Monitoring cleaved caspase-3 activity and apoptosis of immortalized oligodendroglial cells using live-cell imaging and cleaveable fluorogenic-dye substrates following potassium-induced membrane depolarization.Azetidine- and N-carboxylic azetidine-iminosugars as amyloglucosidase inhibitors: synthesis, glycosidase inhibitory activity and molecular docking studies.
P2860
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P2860
Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Proline substitutions and thre ...... calization in oligodendrocytes
@ast
Proline substitutions and thre ...... calization in oligodendrocytes
@en
type
label
Proline substitutions and thre ...... calization in oligodendrocytes
@ast
Proline substitutions and thre ...... calization in oligodendrocytes
@en
prefLabel
Proline substitutions and thre ...... calization in oligodendrocytes
@ast
Proline substitutions and thre ...... calization in oligodendrocytes
@en
P2093
P2860
P921
P3181
P356
P1476
Proline substitutions and thre ...... calization in oligodendrocytes
@en
P2093
Graham S T Smith
Joan M Boggs
Melanie K B Wills
Miguel De Avila
Nina Jones
Vilma Spreuer
P2860
P3181
P356
10.1002/JNR.22733
P577
2011-09-01T00:00:00Z