Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation - Wikidata - awgldk - TriplyDB

Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation

Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation

http://www.wikidata.org/entity/Q30157617

about

Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation.p47phox molecular activation for assembly of the neutrophil NADPH oxidase complex.Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases.A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity.Atypical membrane-embedded phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2)-binding site on p47(phox) Phox homology (PX) domain revealed by NMR.The NOXO1β PX domain preferentially targets PtdIns(4,5)P2 and PtdIns(3,4,5)P3.Conformational changes in p47(phox) upon activation highlighted by mass spectrometry coupled to hydrogen/deuterium exchange and limited proteolysis.

P2860

Q30009954-BAF64E51-A4D6-41DE-AB91-AC8C94FD587C Q30156808-25621474-FA0B-4AD8-8676-3ABFE1A7E101 Q30491877-F90352E8-EBB3-4DF2-969D-910ECBAE269F Q34055834-F4F73CB9-89BA-4B29-ACDB-185684DFFB00 Q36006972-5EC774E6-ACC9-4835-8F2C-BF96E457ADE6 Q41882353-E2FF0C84-DC4F-4B5F-95B5-93ED4D3B94A2 Q46133960-EEC5DF7F-8577-4140-B237-ED20D4A7DB9E

P2860

Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation

http://www.wikidata.org/entity/Q30157617

description

2008 nî lūn-bûn

@nan

2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Mutations in the PX-SH3A linke ...... from NADPH oxidase activation

@ast

Mutations in the PX-SH3A linke ...... from NADPH oxidase activation

@en

type

label

Mutations in the PX-SH3A linke ...... from NADPH oxidase activation

@ast

Mutations in the PX-SH3A linke ...... from NADPH oxidase activation

@en

prefLabel

Mutations in the PX-SH3A linke ...... from NADPH oxidase activation

@ast

Mutations in the PX-SH3A linke ...... from NADPH oxidase activation

@en

P1433

Q30157617-417EB474-DBA9-4133-B1DB-47A40B4E0DFE

P1476

Q30157617-16F00A67-1C01-4836-9E9F-B078B9BD00E6

P2093

Q30157617-AFE1965E-B30C-4A99-A397-E5CE11B9FDC1

Q30157617-B44C4223-C869-4DC0-B031-9C9BD3BAB411

Q30157617-B82DBDE0-5740-453A-B4B0-86B48B78F534

Q30157617-F361724C-3AF2-4018-9B08-4F00D1A47CC3

P2860

Q30157617-024DA301-7BCB-479F-AD36-DBF3609AFCE1

Q30157617-089CFF92-CAC0-4981-B11C-D06AB801CECD

Q30157617-12AC9B7E-40BA-486D-ACDE-AE3A084069C1

Q30157617-12D4B1F6-B06D-422B-892D-E4E37625A0D0

Q30157617-1C0E75E9-32CF-4872-9E6D-EECE8C1EABBE

Q30157617-237C7345-7B15-4FF3-8845-3B4FA10D85D2

Q30157617-27A51798-F377-4841-A723-C696218F6C6E

Q30157617-32AC9ACF-2088-4492-B17A-5020242A39D2

Q30157617-47DDBFE8-0BB6-430B-9BA6-1ED435F6263D

Q30157617-4F24B18B-0743-4AC5-AF3E-685E72E74414

P304

Q30157617-9E83A387-A289-4A23-A36C-723AEF10B417

P31

Q30157617-5E32420E-2A0A-471B-869C-10F6000BDCBD

P356

Q30157617-86B69571-B141-4B5F-B8FB-A4304444D505

P407

Q30157617-6E55162C-9FE0-4029-904D-E5F196AD273D

P433

Q30157617-283BD6CE-EF76-457E-ACB7-C90AF34A2589

P478

Q30157617-516FC159-9F05-42CF-B96F-63359FCD0164

P50

Q30157617-7F806AA4-6974-4360-9F2E-FB7097362340

P577

Q30157617-F27E949F-426A-4269-A326-3C793E5A5CC2

P5875

Q30157617-DA0BCF06-BF7D-4A01-88D4-2FCD03BE46B9

P698

Q30157617-62E7F4C2-C5CD-46EE-9744-BFB949E13046

P921

Q30157617-132AC7E8-74DA-4306-BF50-311F5245CF7F

P932

Q30157617-8F4A8417-9D7D-4826-985D-EF37F8002E12

P356

P1433

P1476

Mutations in the PX-SH3A linke ...... from NADPH oxidase activation

@en

P2093

Kai Shen

http://www.w3.org/2001/XMLSchema#string

Linda C McPhail

http://www.w3.org/2001/XMLSchema#string

Roy R Hantgan

http://www.w3.org/2001/XMLSchema#string

Susan Sergeant

http://www.w3.org/2001/XMLSchema#string

P2860

Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains

Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation

Solution structure of the PX domain, a target of the SH3 domain

Molecular basis of phosphorylation-induced activation of the NADPH oxidase

Structural and membrane binding analysis of the Phox homology domain of Bem1p: basis of phosphatidylinositol 4-phosphate specificity

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

NMR View: A computer program for the visualization and analysis of NMR data

Activation and assembly of the NADPH oxidase: a structural perspective

P304

8855-8865

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/BI8005847

http://www.w3.org/2001/XMLSchema#string

P407

P433

34

http://www.w3.org/2001/XMLSchema#string

P478

47

http://www.w3.org/2001/XMLSchema#string

P50

David A. Horita

P577

2008-08-02T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23143053

http://www.w3.org/2001/XMLSchema#string

P698

18672905

http://www.w3.org/2001/XMLSchema#string

P921

P932

2745045

http://www.w3.org/2001/XMLSchema#string