An electrostatic network and long-range regulation of Src kinases
about
The effect of the cosolvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin CMutations in the catalytic loop HRD motif alter the activity and function of Drosophila Src64Hotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.Locking the active conformation of c-Src kinase through the phosphorylation of the activation loopHierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectoriesComputational studies of H5N1 influenza virus resistance to oseltamivir.Computational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.Sequence and structure signatures of cancer mutation hotspots in protein kinasesComputational insights for the discovery of non-ATP competitive inhibitors of MAP kinasesDynamic, structural and thermodynamic basis of insulin-like growth factor 1 kinase allostery mediated by activation loop phosphorylation.Maximum Flux Transition Paths of Conformational ChangeAutomatic Selection of Order Parameters in the Analysis of Large Scale Molecular Dynamics Simulations.Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases.On the role of electrostatics in protein-protein interactions.Activation pathway of Src kinase reveals intermediate states as targets for drug designConformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90.Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.Heat dissipation guides activation in signaling proteinsEnsembler: Enabling High-Throughput Molecular Simulations at the Superfamily ScaleMolecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing.Lack of Dependence of the Sizes of the Mesoscopic Protein Clusters on ElectrostaticsαC helix as a switch in the conformational transition of Src/CDK-like kinase domains.A Comparison of Three Perturbation Molecular Dynamics Methods for Modeling Conformational Transitions.An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.Myelin architecture: zippering membranes tightly together.Computational study of the W260A activating mutant of Src tyrosine kinase.Evaluating the dynamics and electrostatic interactions of folded proteins in implicit solvents.Functional validation reveals the novel missense V419L variant in TGFBR2 associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-β signalingA dynamically coupled allosteric network underlies binding cooperativity in Src kinase.Hsp90 dependence of a kinase is determined by its conformational landscapeMolecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinasesAtomistic view of the conformational activation of Src kinase using the string method with swarms-of-trajectories.Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain.Molecular dynamics simulations reveal the conformational dynamics of Arabidopsis thaliana BRI1 and BAK1 receptor-like kinases.Recent advances in the understanding of two-step nucleation of protein crystals.
P2860
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P2860
An electrostatic network and long-range regulation of Src kinases
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
An electrostatic network and long-range regulation of Src kinases
@ast
An electrostatic network and long-range regulation of Src kinases
@en
type
label
An electrostatic network and long-range regulation of Src kinases
@ast
An electrostatic network and long-range regulation of Src kinases
@en
prefLabel
An electrostatic network and long-range regulation of Src kinases
@ast
An electrostatic network and long-range regulation of Src kinases
@en
P2093
P2860
P356
P1433
P1476
An electrostatic network and long-range regulation of Src kinases
@en
P2093
Carol Beth Post
Elif Ozkirimli
Shalini S Yadav
W Todd Miller
P2860
P304
P356
10.1110/PS.037457.108
P577
2008-08-07T00:00:00Z