Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
about
Huntingtin interacting proteins are genetic modifiers of neurodegenerationHuntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicityConnecting the dots in Huntington's disease with protein interaction networksIntrabodies as neuroprotective therapeuticsAutophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?Genetics and neuropathology of Huntington's diseaseStructure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR ApproachHuntingtin inhibits caspase-3 activationA series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesiDeletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in miceBiophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes.Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease.Mutant huntingtin can paradoxically protect neurons from death.Modeling Huntington disease in yeast: perspectives and future directions.Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation.Conserved genes act as modifiers of invertebrate SMN loss of function defectsUse of Genetically Altered Stem Cells for the Treatment of Huntington's Disease.Drosophila models of neurodegenerative diseaseHuntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cellsPolyglutamine repeats are associated to specific sequence biases that are conserved among eukaryotes.Therapeutic approaches to preventing cell death in Huntington diseasePolyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance.Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology.Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases.Flanking sequences profoundly alter polyglutamine toxicity in yeast.Gene therapy in mouse models of huntington disease.Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA).Selection and characterization of llama single domain antibodies against N-terminal huntingtinCAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse.Native mutant huntingtin in human brain: evidence for prevalence of full-length monomerThe emerging role of the first 17 amino acids of huntingtin in Huntington's diseaseProteolytic mechanisms in necrotic cell death and neurodegeneration.The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies.Knock-in mouse models of Huntington's disease.Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge
P2860
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P2860
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Huntingtin bodies sequester ve ...... proline-dependent interaction.
@ast
Huntingtin bodies sequester ve ...... proline-dependent interaction.
@en
type
label
Huntingtin bodies sequester ve ...... proline-dependent interaction.
@ast
Huntingtin bodies sequester ve ...... proline-dependent interaction.
@en
prefLabel
Huntingtin bodies sequester ve ...... proline-dependent interaction.
@ast
Huntingtin bodies sequester ve ...... proline-dependent interaction.
@en
P2093
P1476
Huntingtin bodies sequester ve ...... yproline-dependent interaction
@en
P2093
Benjamin Cuiffo
Ellen Sapp
Kimberly B Kegel
Marian DiFiglia
Neil Aronin
Yumei Wang
Zheng-Hong Qin
P304
P356
10.1523/JNEUROSCI.1409-03.2004
P407
P577
2004-01-01T00:00:00Z