The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.
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Identification of the WW domain-interaction sites in the unstructured N-terminal domain of EBV LMP 2ALatent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinasesWW domains provide a platform for the assembly of multiprotein networksIdentification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functionsEpstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling moduleActivation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane proteinUbiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channelThe non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.Role of the ubiquitin system and tumor viruses in AIDS-related cancer.The LMP2A ITAM is essential for providing B cells with development and survival signals in vivoUbiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation.Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signalingLatent membrane protein 2A-mediated effects on the phosphatidylinositol 3-Kinase/Akt pathway.PY motifs of Epstein-Barr virus LMP2A regulate protein stability and phosphorylation of LMP2A-associated proteins.Epstein-Barr virus (EBV) latent membrane protein 2A regulates B-cell receptor-induced apoptosis and EBV reactivation through tyrosine phosphorylation.C-terminal domain of the Epstein-Barr virus LMP2A membrane protein contains a clustering signalDegradation of the epstein-barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway. Targeting via ubiquitination of the N-terminal residue.Epstein-Barr virus latent membrane protein-2A-induced DeltaNp63alpha expression is associated with impaired epithelial-cell differentiationThe expression and function of Epstein-Barr virus encoded latent genesEpstein-Barr virus latent membrane protein 2A regulates c-Jun protein through extracellular signal-regulated kinase.The effects of the Epstein-Barr virus latent membrane protein 2A on B cell function.Itchy, a Nedd4 ubiquitin ligase, downregulates latent membrane protein 2A activity in B-cell signaling.Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity.The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture.Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system.Cholesterol is critical for Epstein-Barr virus latent membrane protein 2A trafficking and protein stabilityEpstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell survivalEpstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through αv-integrin membrane translocation.An auto-regulatory loop for EBV LMP2A involves activation of Notch.The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance.Epstein-Barr virus latent membrane protein 2A preferentially signals through the Src family kinase LynEpstein-Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells.Differential effects of actin cytoskeleton dynamics on equine infectious anemia virus particle productionThe functionally exchangeable L domains in RSV and HIV-1 Gag direct particle release through pathways linked by Tsg101Epstein-Barr virus latent membrane protein 2 effects on epithelial acinus development reveal distinct requirements for the PY and YEEA motifsThe c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling.LMP2A does not require palmitoylation to localize to buoyant complexes or for function.Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells.The ubiquitin-conjugating system: multiple roles in viral replication and infection.
P2860
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P2860
The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մարտին հրատարակուած գիտական յօդուած
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2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The Epstein-Barr virus latent ...... ing ubiquitin-protein ligases.
@ast
The Epstein-Barr virus latent ...... ing ubiquitin-protein ligases.
@en
type
label
The Epstein-Barr virus latent ...... ing ubiquitin-protein ligases.
@ast
The Epstein-Barr virus latent ...... ing ubiquitin-protein ligases.
@en
prefLabel
The Epstein-Barr virus latent ...... ing ubiquitin-protein ligases.
@ast
The Epstein-Barr virus latent ...... ing ubiquitin-protein ligases.
@en
P2093
P356
P1433
P1476
The Epstein-Barr virus latent ...... ing ubiquitin-protein ligases.
@en
P2093
P304
P356
10.1006/VIRO.1999.0166
P407
P577
2000-03-01T00:00:00Z