HIV-2 and SIV nef proteins target different Src family SH3 domains than does HIV-1 Nef because of a triple amino acid substitution.
about
Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction.The pathogenicity of human immunodeficiency virus (HIV) type 1 Nef in CD4C/HIV transgenic mice is abolished by mutation of its SH3-binding domain, and disease development is delayed in the absence of Hck.Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes.Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease.Protein trafficking dysfunctions: Role in the pathogenesis of pulmonary arterial hypertension.Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques.GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.
P2860
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P2860
HIV-2 and SIV nef proteins target different Src family SH3 domains than does HIV-1 Nef because of a triple amino acid substitution.
description
2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
HIV-2 and SIV nef proteins tar ...... riple amino acid substitution.
@ast
HIV-2 and SIV nef proteins tar ...... riple amino acid substitution.
@en
type
label
HIV-2 and SIV nef proteins tar ...... riple amino acid substitution.
@ast
HIV-2 and SIV nef proteins tar ...... riple amino acid substitution.
@en
prefLabel
HIV-2 and SIV nef proteins tar ...... riple amino acid substitution.
@ast
HIV-2 and SIV nef proteins tar ...... riple amino acid substitution.
@en
P2093
P2860
P356
P1476
HIV-2 and SIV nef proteins tar ...... riple amino acid substitution.
@en
P2093
Benarous R
Benichou S
Collette Y
P2860
P304
P356
10.1074/JBC.275.6.4171
P407
P577
2000-02-01T00:00:00Z