The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase
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Structural rearrangement of human lymphotactin, a C chemokine, under physiological solution conditionsIdentification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein XIdentification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinaseStructure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulationThe Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)Myristoyl moiety of HIV Nef is involved in regulation of the interaction with calmodulin in vivoMutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functionsActivation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complexSubunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptinsSeparable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signalingCo-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulationInterleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathwayInteraction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivityStructure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4Structure and ubiquitin binding of the ubiquitin-interacting motifStructure of Mth11/Mth Rpp29, an essential protein subunit of archaeal and eukaryotic RNase PMolecular characterization of the Ran-binding zinc finger domain of Nup153The solution structures of two soybean calmodulin isoforms provide a structural basis for their selective target activation propertiesSolution structure of the calponin homology (CH) domain from the smoothelin-like 1 protein: a unique apocalmodulin-binding mode and the possible role of the C-terminal type-2 CH-domain in smooth muscle relaxationStructural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domainsStructural Studies of Soybean Calmodulin Isoform 4 Bound to the Calmodulin-binding Domain of Tobacco Mitogen-activated Protein Kinase Phosphatase-1 Provide Insights into a Sequential Target Binding ModeStructural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4ENMR Structure of the First Extracellular Domain of Corticotropin-releasing Factor Receptor 1 (ECD1-CRF-R1) Complexed with a High Affinity AgonistSolution Structures of Ca 2+ -CIB1 and Mg 2+ -CIB1 and Their Interactions with the Platelet Integrin αIIb Cytoplasmic DomainStructure of a Specialized Acyl Carrier Protein Essential for Lipid A Biosynthesis with Very Long-Chain Fatty Acids in Open and Closed ConformationsStructural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) ActivationStructural mechanism of Bax inhibition by cytomegalovirus protein vMIAStructural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibitedStructural Insights into Calmodulin-regulated L-selectin Ectodomain SheddingHow HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid-virus pSSVx: a novel peculiar member of the winged helix-turn-helix transcription factor familyThe cytochrome c peroxidase and cytochrome c encounter complex: the other side of the story.Monomeric yeast frataxin is an iron-binding protein.Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor NefStructural characterization of the interaction of human lactoferrin with calmodulinHydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitmentThe accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.
P2860
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P2860
The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase
description
1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1996
@ast
scientific journal article
@en
vedecký článok (publikovaný 1996/04/01)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/04/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована у квітні 1996
@uk
مقالة علمية (نشرت في أبريل 1996)
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name
The solution structure of HIV- ...... of Hck tyrosine protein kinase
@ast
The solution structure of HIV- ...... of Hck tyrosine protein kinase
@en
The solution structure of HIV- ...... of Hck tyrosine protein kinase
@nl
type
label
The solution structure of HIV- ...... of Hck tyrosine protein kinase
@ast
The solution structure of HIV- ...... of Hck tyrosine protein kinase
@en
The solution structure of HIV- ...... of Hck tyrosine protein kinase
@nl
prefLabel
The solution structure of HIV- ...... of Hck tyrosine protein kinase
@ast
The solution structure of HIV- ...... of Hck tyrosine protein kinase
@en
The solution structure of HIV- ...... of Hck tyrosine protein kinase
@nl
P2093
P2860
P50
P921
P356
P1476
The solution structure of HIV- ...... of Hck tyrosine protein kinase
@en
P2093
P2860
P304
P356
10.1038/NSB0496-340
P577
1996-04-01T00:00:00Z